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Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study
المؤلفون المشاركون
Qu, Shanshan
Zhang, Jiping
Huang, Yong
Zhong, Zheng
Zhang, Jialing
Zhang, Zhinan
Yao, Zengyu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Electroacupuncture (EA) is considered a complementary therapy for depression.
Trials also found that EA has additive benefits when combined with medication compared with medication alone.
It is revealed that EA restores altered hippocampal synaptic plasticity in depressed brain.
But precise molecular mechanism is poorly understood.
Here, we evaluated the therapeutic effects of EA and EA combined with selective serotonin reuptake inhibitor (SSRI) on depressed (CUMS) rats.
Then a new proteomics approach, isobaric tag for relative and absolute quantitation (iTRAQ), was used to explore the differential expressed synaptic protein in hippocampus between CUMS and EA-treated rats to identify the possible target molecular mechanism of its effects.
We found that EA had additive benefit against depressive behaviors when combined with SSRI.
Ultrastructure study on neuron showed significant change in postsynapse density (PSD) and mitochondrion.
Through iTRAQ, it is found that synaptic and mitochondrial proteins were significantly changed after EA, consisting with ultrastructure study results.
These findings suggest that EA improves antidepressant performance in depressed rats through protecting synaptic and mitochondrial functions in hippocampus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Jialing& Zhang, Zhinan& Zhang, Jiping& Zhong, Zheng& Yao, Zengyu& Qu, Shanshan…[et al.]. 2019. Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1149416
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Jialing…[et al.]. Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1149416
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Jialing& Zhang, Zhinan& Zhang, Jiping& Zhong, Zheng& Yao, Zengyu& Qu, Shanshan…[et al.]. Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1149416
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149416
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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