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Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study
Joint Authors
Qu, Shanshan
Zhang, Jiping
Huang, Yong
Zhong, Zheng
Zhang, Jialing
Zhang, Zhinan
Yao, Zengyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Electroacupuncture (EA) is considered a complementary therapy for depression.
Trials also found that EA has additive benefits when combined with medication compared with medication alone.
It is revealed that EA restores altered hippocampal synaptic plasticity in depressed brain.
But precise molecular mechanism is poorly understood.
Here, we evaluated the therapeutic effects of EA and EA combined with selective serotonin reuptake inhibitor (SSRI) on depressed (CUMS) rats.
Then a new proteomics approach, isobaric tag for relative and absolute quantitation (iTRAQ), was used to explore the differential expressed synaptic protein in hippocampus between CUMS and EA-treated rats to identify the possible target molecular mechanism of its effects.
We found that EA had additive benefit against depressive behaviors when combined with SSRI.
Ultrastructure study on neuron showed significant change in postsynapse density (PSD) and mitochondrion.
Through iTRAQ, it is found that synaptic and mitochondrial proteins were significantly changed after EA, consisting with ultrastructure study results.
These findings suggest that EA improves antidepressant performance in depressed rats through protecting synaptic and mitochondrial functions in hippocampus.
American Psychological Association (APA)
Zhang, Jialing& Zhang, Zhinan& Zhang, Jiping& Zhong, Zheng& Yao, Zengyu& Qu, Shanshan…[et al.]. 2019. Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1149416
Modern Language Association (MLA)
Zhang, Jialing…[et al.]. Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1149416
American Medical Association (AMA)
Zhang, Jialing& Zhang, Zhinan& Zhang, Jiping& Zhong, Zheng& Yao, Zengyu& Qu, Shanshan…[et al.]. Electroacupuncture Improves Antidepressant Effects in CUMS Rats by Protecting Hippocampal Synapse and Mitochondrion: An Ultrastructural and iTRAQ Proteomic Study. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1149416
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149416