Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA1 Mice
المؤلفون المشاركون
Nho, Jong-Hyun
Kim, A-Hyeon
Jung, Ho-Kyung
Lee, Mu-Jin
Jang, Ji-Hun
Yang, Beo-Dul
Lee, Hyun-Ju
Lee, Ki-Ho
Woo, Kyeong-Wan
Cho, Hyun-Woo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-01
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The dry rhizome of Acorus gramineus Solander, known as Acori Graminei Rhizoma, is used to treat dementia, stroke, eczema, and indigestion in traditional Chinese medicine, traditional Korean medicine, and traditional Japanese Kampo medicine.
Previous studies have reported that Acori Graminei Rhizoma extract ameliorated cognitive impairment in Aβ1-42 injected mice.
However, the effect of Acori Graminei Rhizoma on type II collagen induced arthritis (CIA) has not been elucidated.
Thus, we evaluated the water extract of Acori Graminei Rhizoma (WAG) in CIA mice models.
Male DBA/1 mice were separated into five groups (NOR; n=10, CON; n=10, CIA + methotrexate (MTX); n=10, CIA + 100 mg/kg WAG; n=10, CIA + 500 mg/kg WAG; n=10).
CIA was induced by injecting the mice with bovine type II collagen, after which the mice were treated with WAG and/or MTX.
Hematological parameters and liver and kidney serum toxicity markers were analyzed.
Further, serum levels of interleukin (IL)-6, TNF-α, and type II collagen IgG were analyzed via enzyme-linked immunosorbent assay (ELISA).
Treatment with 500 mg/kg WAG decreased serum levels of IL-6, TNF-α, and collagen IgG in a CIA model.
Moreover, WAG treatment decreased CIA-induced swelling of mouse hind legs, infiltration of inflammatory cells into the synovial membrane, and blood neutrophil levels.
WAG administration did not influence hematological parameters or kidneys and liver toxicity markers.
WAG may be used to treat arthritis by reducing the inflammation indicators.
However, further experiments are required to determine how WAG affects inflammation mechanisms in vitro and in vivo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nho, Jong-Hyun& Kim, A-Hyeon& Jung, Ho-Kyung& Lee, Mu-Jin& Jang, Ji-Hun& Yang, Beo-Dul…[et al.]. 2019. Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA1 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1149504
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nho, Jong-Hyun…[et al.]. Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA1 Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1149504
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nho, Jong-Hyun& Kim, A-Hyeon& Jung, Ho-Kyung& Lee, Mu-Jin& Jang, Ji-Hun& Yang, Beo-Dul…[et al.]. Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA1 Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1149504
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149504
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر