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Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA1 Mice
Joint Authors
Nho, Jong-Hyun
Kim, A-Hyeon
Jung, Ho-Kyung
Lee, Mu-Jin
Jang, Ji-Hun
Yang, Beo-Dul
Lee, Hyun-Ju
Lee, Ki-Ho
Woo, Kyeong-Wan
Cho, Hyun-Woo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The dry rhizome of Acorus gramineus Solander, known as Acori Graminei Rhizoma, is used to treat dementia, stroke, eczema, and indigestion in traditional Chinese medicine, traditional Korean medicine, and traditional Japanese Kampo medicine.
Previous studies have reported that Acori Graminei Rhizoma extract ameliorated cognitive impairment in Aβ1-42 injected mice.
However, the effect of Acori Graminei Rhizoma on type II collagen induced arthritis (CIA) has not been elucidated.
Thus, we evaluated the water extract of Acori Graminei Rhizoma (WAG) in CIA mice models.
Male DBA/1 mice were separated into five groups (NOR; n=10, CON; n=10, CIA + methotrexate (MTX); n=10, CIA + 100 mg/kg WAG; n=10, CIA + 500 mg/kg WAG; n=10).
CIA was induced by injecting the mice with bovine type II collagen, after which the mice were treated with WAG and/or MTX.
Hematological parameters and liver and kidney serum toxicity markers were analyzed.
Further, serum levels of interleukin (IL)-6, TNF-α, and type II collagen IgG were analyzed via enzyme-linked immunosorbent assay (ELISA).
Treatment with 500 mg/kg WAG decreased serum levels of IL-6, TNF-α, and collagen IgG in a CIA model.
Moreover, WAG treatment decreased CIA-induced swelling of mouse hind legs, infiltration of inflammatory cells into the synovial membrane, and blood neutrophil levels.
WAG administration did not influence hematological parameters or kidneys and liver toxicity markers.
WAG may be used to treat arthritis by reducing the inflammation indicators.
However, further experiments are required to determine how WAG affects inflammation mechanisms in vitro and in vivo.
American Psychological Association (APA)
Nho, Jong-Hyun& Kim, A-Hyeon& Jung, Ho-Kyung& Lee, Mu-Jin& Jang, Ji-Hun& Yang, Beo-Dul…[et al.]. 2019. Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA1 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1149504
Modern Language Association (MLA)
Nho, Jong-Hyun…[et al.]. Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA1 Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1149504
American Medical Association (AMA)
Nho, Jong-Hyun& Kim, A-Hyeon& Jung, Ho-Kyung& Lee, Mu-Jin& Jang, Ji-Hun& Yang, Beo-Dul…[et al.]. Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA1 Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1149504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149504