Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models
المؤلفون المشاركون
Gong, Yuewen
Xi, Shengyan
Yue, Lifeng
Xu, Yangxinzi
Qian, Lin-chao
Fu, Biqian
Zhai, Xiangyang
Wang, Yanan
Qiu, Yingkun
Huang, Jingru
Lu, Dawei
Huang, Shuqiong
Wang, Jing
Zhou, Jing
Wu, Di
Wang, Yanhui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-14
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Background.
Ciji-Hua’ai-Baosheng II Formula (CHB-II-F) is a new traditional Chinese medical formula that has been shown to reduce toxicity and side effects of chemotherapy and increase the probability of cancer patient survival.
Whether CHB-II-F is safe as an adjunctive therapy for cancer patients receiving chemotherapy has yet to be determined.
Purpose.
To evaluate the acute and subchronic toxic effects of CHB-II-F in rodent models.
Methods.
In acute toxicity test, 24 Kunming mice were divided into 2 groups: untreated control and CHB-II-F 1.05 g/mL (31.44 g/kg) treated group.
Treatment was administered to the treated group 3 times a day for 14 days.
The overall health, adverse reactions, and mortality rate were documented.
In subchronic toxicity test, 96 Sprague-Dawley rats were divided into 4 groups: untreated control, high dose CHB-II-F (H) (26.20 g/kg), medium dose CHB-II-F (M) (13.
10 g/kg), and low dose CHB-II-F (L) (6.55 g/kg) [equal to 24.375 g (dried medicinal herb)/kg] treated groups.
Treated groups were given the treatments once a day for 4 weeks.
The overall health and mortality rate were recorded every day.
Body weight and food consumption were measured once a week.
Hematologic and biochemical parameters, organ weights, and histopathologic markers were analyzed after 4 weeks.
An additional 2 weeks were given as the treatment recovery period before end-point euthanization, and biochemical analyses were performed.
Results.
The maximum tolerated dose (MTD) of CHB-II-F on mice was found to be 94.31 g/kg [equal to 351 g (dried medicinal herb)/kg], which is 108 times the human adult dose.
In the acute toxicity test, administration of CHB-II-F 31.44 g/kg showed no adverse effect and did not cause mortality.
In the subchronic toxicity test, after 4 weeks of treatment, compared to the controls, total cholesterol (TCHO) level, cardiac and splenic indexes, body weights of female rats, and mean corpuscular hemoglobin concentration (MCHC) in the CHB-II-F (H) group were significantly increased; triglyceride (TG) in the CHB-II-F (M) group and liver and splenic indexes in the CHB-II-F (L) group were increased.
After the two-week recovery period, biofluid analyses, food consumption, and histopathologic examinations showed no abnormalities.
Conclusion.
Administration of CHB-II-F had no obvious adverse effect on the overall health of rodent models.
A daily maximum dose of less than 94.31 g/kg or 6.55 g/kg CHB-II-F for 4 continuous weeks was considered safe.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Biqian& Zhai, Xiangyang& Xi, Shengyan& Yue, Lifeng& Wang, Yanan& Qiu, Yingkun…[et al.]. 2019. Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1149526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Biqian…[et al.]. Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-21.
https://search.emarefa.net/detail/BIM-1149526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Biqian& Zhai, Xiangyang& Xi, Shengyan& Yue, Lifeng& Wang, Yanan& Qiu, Yingkun…[et al.]. Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1149526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر