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Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models
Joint Authors
Gong, Yuewen
Xi, Shengyan
Yue, Lifeng
Xu, Yangxinzi
Qian, Lin-chao
Fu, Biqian
Zhai, Xiangyang
Wang, Yanan
Qiu, Yingkun
Huang, Jingru
Lu, Dawei
Huang, Shuqiong
Wang, Jing
Zhou, Jing
Wu, Di
Wang, Yanhui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-14
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Background.
Ciji-Hua’ai-Baosheng II Formula (CHB-II-F) is a new traditional Chinese medical formula that has been shown to reduce toxicity and side effects of chemotherapy and increase the probability of cancer patient survival.
Whether CHB-II-F is safe as an adjunctive therapy for cancer patients receiving chemotherapy has yet to be determined.
Purpose.
To evaluate the acute and subchronic toxic effects of CHB-II-F in rodent models.
Methods.
In acute toxicity test, 24 Kunming mice were divided into 2 groups: untreated control and CHB-II-F 1.05 g/mL (31.44 g/kg) treated group.
Treatment was administered to the treated group 3 times a day for 14 days.
The overall health, adverse reactions, and mortality rate were documented.
In subchronic toxicity test, 96 Sprague-Dawley rats were divided into 4 groups: untreated control, high dose CHB-II-F (H) (26.20 g/kg), medium dose CHB-II-F (M) (13.
10 g/kg), and low dose CHB-II-F (L) (6.55 g/kg) [equal to 24.375 g (dried medicinal herb)/kg] treated groups.
Treated groups were given the treatments once a day for 4 weeks.
The overall health and mortality rate were recorded every day.
Body weight and food consumption were measured once a week.
Hematologic and biochemical parameters, organ weights, and histopathologic markers were analyzed after 4 weeks.
An additional 2 weeks were given as the treatment recovery period before end-point euthanization, and biochemical analyses were performed.
Results.
The maximum tolerated dose (MTD) of CHB-II-F on mice was found to be 94.31 g/kg [equal to 351 g (dried medicinal herb)/kg], which is 108 times the human adult dose.
In the acute toxicity test, administration of CHB-II-F 31.44 g/kg showed no adverse effect and did not cause mortality.
In the subchronic toxicity test, after 4 weeks of treatment, compared to the controls, total cholesterol (TCHO) level, cardiac and splenic indexes, body weights of female rats, and mean corpuscular hemoglobin concentration (MCHC) in the CHB-II-F (H) group were significantly increased; triglyceride (TG) in the CHB-II-F (M) group and liver and splenic indexes in the CHB-II-F (L) group were increased.
After the two-week recovery period, biofluid analyses, food consumption, and histopathologic examinations showed no abnormalities.
Conclusion.
Administration of CHB-II-F had no obvious adverse effect on the overall health of rodent models.
A daily maximum dose of less than 94.31 g/kg or 6.55 g/kg CHB-II-F for 4 continuous weeks was considered safe.
American Psychological Association (APA)
Fu, Biqian& Zhai, Xiangyang& Xi, Shengyan& Yue, Lifeng& Wang, Yanan& Qiu, Yingkun…[et al.]. 2019. Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1149526
Modern Language Association (MLA)
Fu, Biqian…[et al.]. Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-21.
https://search.emarefa.net/detail/BIM-1149526
American Medical Association (AMA)
Fu, Biqian& Zhai, Xiangyang& Xi, Shengyan& Yue, Lifeng& Wang, Yanan& Qiu, Yingkun…[et al.]. Safety Evaluation of a New Traditional Chinese Medical Formula, Ciji-Hua’ai-Baosheng II Formula, in Adult Rodent Models. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-21.
https://search.emarefa.net/detail/BIM-1149526
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149526