Hirsutella sinensis Treatment Shows Protective Effects on Renal Injury and Metabolic Modulation in dbdb Mice
المؤلفون المشاركون
Aa, JiYe
Lu, Zhenyao
Li, Sijia
Sun, Runbin
Jia, Xue
Xu, Chen
Wang, Guangji
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-04
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Hirsutella sinensis (HS) is the anamorph of the traditional Chinese medicine Cordyceps sinensis.
Although the renal protective effect of HS has been reported, its effect on diabetic nephropathy (DN) remains unclear.
In this study, db/db mice were used as the DN model, and the renal protective effect was evaluated after oral administration of HS for 6 and 12 weeks.
Plasma, urine, and kidney samples were collected, and biochemical indicator measurements, pathological analysis, and metabolomics studies were performed.
Biochemical assays showed that HS reduced the levels of fasting blood glucose (FBG), urinary albumin/creatinine ratio (ACR), and N-acetyl-beta-D-glucosaminidase (NAG) and increased the creatinine clearance (Ccr).
HS alleviated glomerular and tubular glycogen accumulation and fibrosis and normalized the disordered ultrastructure of the glomerular filtration barrier.
Metabolomics analysis of metabolites in the plasma, urine, and kidney indicated that HS modulated the perturbed glycolipid metabolism and amino acid turnover.
HS reduced the elevated levels of metabolites involved in energy metabolism (TCA cycle, glycolysis, and pentose phosphate pathway) and nucleotide metabolism (pyrimidine metabolism and purine metabolism) in the kidneys of db/db mice.
These results suggest that HS can protect against renal injury and that its efficacy involved metabolic modulation of the disturbed metabolome in db/db mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Zhenyao& Li, Sijia& Sun, Runbin& Jia, Xue& Xu, Chen& Aa, JiYe…[et al.]. 2019. Hirsutella sinensis Treatment Shows Protective Effects on Renal Injury and Metabolic Modulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149896
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Zhenyao…[et al.]. Hirsutella sinensis Treatment Shows Protective Effects on Renal Injury and Metabolic Modulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1149896
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Zhenyao& Li, Sijia& Sun, Runbin& Jia, Xue& Xu, Chen& Aa, JiYe…[et al.]. Hirsutella sinensis Treatment Shows Protective Effects on Renal Injury and Metabolic Modulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149896
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149896
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر