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Hirsutella sinensis Treatment Shows Protective Effects on Renal Injury and Metabolic Modulation in dbdb Mice
Joint Authors
Aa, JiYe
Lu, Zhenyao
Li, Sijia
Sun, Runbin
Jia, Xue
Xu, Chen
Wang, Guangji
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-04
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Hirsutella sinensis (HS) is the anamorph of the traditional Chinese medicine Cordyceps sinensis.
Although the renal protective effect of HS has been reported, its effect on diabetic nephropathy (DN) remains unclear.
In this study, db/db mice were used as the DN model, and the renal protective effect was evaluated after oral administration of HS for 6 and 12 weeks.
Plasma, urine, and kidney samples were collected, and biochemical indicator measurements, pathological analysis, and metabolomics studies were performed.
Biochemical assays showed that HS reduced the levels of fasting blood glucose (FBG), urinary albumin/creatinine ratio (ACR), and N-acetyl-beta-D-glucosaminidase (NAG) and increased the creatinine clearance (Ccr).
HS alleviated glomerular and tubular glycogen accumulation and fibrosis and normalized the disordered ultrastructure of the glomerular filtration barrier.
Metabolomics analysis of metabolites in the plasma, urine, and kidney indicated that HS modulated the perturbed glycolipid metabolism and amino acid turnover.
HS reduced the elevated levels of metabolites involved in energy metabolism (TCA cycle, glycolysis, and pentose phosphate pathway) and nucleotide metabolism (pyrimidine metabolism and purine metabolism) in the kidneys of db/db mice.
These results suggest that HS can protect against renal injury and that its efficacy involved metabolic modulation of the disturbed metabolome in db/db mice.
American Psychological Association (APA)
Lu, Zhenyao& Li, Sijia& Sun, Runbin& Jia, Xue& Xu, Chen& Aa, JiYe…[et al.]. 2019. Hirsutella sinensis Treatment Shows Protective Effects on Renal Injury and Metabolic Modulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149896
Modern Language Association (MLA)
Lu, Zhenyao…[et al.]. Hirsutella sinensis Treatment Shows Protective Effects on Renal Injury and Metabolic Modulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1149896
American Medical Association (AMA)
Lu, Zhenyao& Li, Sijia& Sun, Runbin& Jia, Xue& Xu, Chen& Aa, JiYe…[et al.]. Hirsutella sinensis Treatment Shows Protective Effects on Renal Injury and Metabolic Modulation in dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149896