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Antioxidant Properties of Unripe Carica papaya Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress
المؤلفون المشاركون
Wattanapitayakul, Suvara K.
Jarisarapurin, Wattanased
Sanrattana, Wariya
Kunchana, Khwandow
Chularojmontri, Linda
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-20
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
It has been proven that high consumption of fruit and vegetable lowers the risks of cardiovascular and other oxidative stress-related diseases.
Here we evaluated the effects of a tropical fruit, unripe Carica papaya (UCP), on endothelial protection against oxidative damage induced by H2O2.
The antioxidant properties of UCP were investigated using the assays of FRAP and ORAC and specific ROS scavenging activities (H2O2, O 2 • - , OH•, HOCl).
Cytoprotective property was tested in human endothelial cell line EA.hy926 with respect to cell survival, intracellular ROS levels, antioxidant enzyme activities (CAT, SOD, GPX), survival/stress signaling (AKT, JNK, p38), and nuclear signaling (Nrf2, NF-kB).
UCP processed high antioxidant activity and scavenging activity against H2O2> OH•> O 2 • - > HOCl, respectively.
UCP improved cell survival in the milieu of ROS reduction.
While SOD was increased by UCP, CAT activity was enhanced when cells were challenged with H2O2.
UCP had no impact on H2O2-activated AKT, JNK, and p38 signaling but significantly decreased nuclear NF-κB levels.
The overactivation of Nrf2 in response to oxidative stress was constrained by UCP.
In conclusion, UCP protected endothelial cells against oxidative damage through intracellular ROS reduction, enhanced CAT activity, suppression of NF-kB, and prohibition of Nrf2 dysregulation.
Thus, UCP might be a candidate for development of nutraceuticals against CVD and oxidative-related diseases and conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jarisarapurin, Wattanased& Sanrattana, Wariya& Chularojmontri, Linda& Kunchana, Khwandow& Wattanapitayakul, Suvara K.. 2019. Antioxidant Properties of Unripe Carica papaya Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149949
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jarisarapurin, Wattanased…[et al.]. Antioxidant Properties of Unripe Carica papaya Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1149949
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jarisarapurin, Wattanased& Sanrattana, Wariya& Chularojmontri, Linda& Kunchana, Khwandow& Wattanapitayakul, Suvara K.. Antioxidant Properties of Unripe Carica papaya Fruit Extract and Its Protective Effects against Endothelial Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1149949
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149949
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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