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Qingshen Buyang Formula Attenuates Renal Fibrosis in 56 Nephrectomized Rats via Inhibiting EMT and Wntβ-Catenin Pathway
المؤلفون المشاركون
Zhang, Xueqin
Fang, Jing
Chen, Zhiqiang
Zhao, Bingwu
Wu, Su
Pan, Yongmei
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
As renal fibrosis significantly contributes to various kinds of chronic kidney diseases, this study aimed to investigate the renal protective effects of Qingshen Buyang Formula against renal fibrosis on 5/6 nephrectomized rats, and its underlying mechanisms were explored.
A total of 24 male Sprague-Dawley rats were randomly divided into sham operation group (Sham group), 5/6 nephrectomy group (5/6Nx group), and Qingshen Buyang Formula treatment group (QBF group).
The intervention was intragastric administration for 12 weeks.
In the end, the blood samples were collected to test renal functional parameters, urine proteins were measured, and the left kidneys were removed for histological studies, as well as mRNA and protein expression analysis.
The results showed that Qingshen Buyang Formula significantly decreased BUN, Scr, and proteinuria in 5/6Nx rats.
Meanwhile, it ameliorated the kidney injury and fibrosis, exemplified by the depressed expression of collagen I and fibronectin (FN), which are the main components of ECM.
Furthermore, the process of EMT inhibited the Wnt/β-catenin signaling pathway related genes, such as Wnt4, TCF4, β-catenin, and p-GSK3β.
Collectively, the Qingshen Buyang Formula can improve renal function and attenuate renal fibrosis, and its underlying mechanisms may be related with inhibiting EMT and Wnt/β-catenin signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Xueqin& Fang, Jing& Chen, Zhiqiang& Zhao, Bingwu& Wu, Su& Pan, Yongmei. 2019. Qingshen Buyang Formula Attenuates Renal Fibrosis in 56 Nephrectomized Rats via Inhibiting EMT and Wntβ-Catenin Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150120
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Xueqin…[et al.]. Qingshen Buyang Formula Attenuates Renal Fibrosis in 56 Nephrectomized Rats via Inhibiting EMT and Wntβ-Catenin Pathway. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150120
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Xueqin& Fang, Jing& Chen, Zhiqiang& Zhao, Bingwu& Wu, Su& Pan, Yongmei. Qingshen Buyang Formula Attenuates Renal Fibrosis in 56 Nephrectomized Rats via Inhibiting EMT and Wntβ-Catenin Pathway. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150120
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150120
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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