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Qingshen Buyang Formula Attenuates Renal Fibrosis in 56 Nephrectomized Rats via Inhibiting EMT and Wntβ-Catenin Pathway
Joint Authors
Zhang, Xueqin
Fang, Jing
Chen, Zhiqiang
Zhao, Bingwu
Wu, Su
Pan, Yongmei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
As renal fibrosis significantly contributes to various kinds of chronic kidney diseases, this study aimed to investigate the renal protective effects of Qingshen Buyang Formula against renal fibrosis on 5/6 nephrectomized rats, and its underlying mechanisms were explored.
A total of 24 male Sprague-Dawley rats were randomly divided into sham operation group (Sham group), 5/6 nephrectomy group (5/6Nx group), and Qingshen Buyang Formula treatment group (QBF group).
The intervention was intragastric administration for 12 weeks.
In the end, the blood samples were collected to test renal functional parameters, urine proteins were measured, and the left kidneys were removed for histological studies, as well as mRNA and protein expression analysis.
The results showed that Qingshen Buyang Formula significantly decreased BUN, Scr, and proteinuria in 5/6Nx rats.
Meanwhile, it ameliorated the kidney injury and fibrosis, exemplified by the depressed expression of collagen I and fibronectin (FN), which are the main components of ECM.
Furthermore, the process of EMT inhibited the Wnt/β-catenin signaling pathway related genes, such as Wnt4, TCF4, β-catenin, and p-GSK3β.
Collectively, the Qingshen Buyang Formula can improve renal function and attenuate renal fibrosis, and its underlying mechanisms may be related with inhibiting EMT and Wnt/β-catenin signaling pathway.
American Psychological Association (APA)
Zhang, Xueqin& Fang, Jing& Chen, Zhiqiang& Zhao, Bingwu& Wu, Su& Pan, Yongmei. 2019. Qingshen Buyang Formula Attenuates Renal Fibrosis in 56 Nephrectomized Rats via Inhibiting EMT and Wntβ-Catenin Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150120
Modern Language Association (MLA)
Zhang, Xueqin…[et al.]. Qingshen Buyang Formula Attenuates Renal Fibrosis in 56 Nephrectomized Rats via Inhibiting EMT and Wntβ-Catenin Pathway. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150120
American Medical Association (AMA)
Zhang, Xueqin& Fang, Jing& Chen, Zhiqiang& Zhao, Bingwu& Wu, Su& Pan, Yongmei. Qingshen Buyang Formula Attenuates Renal Fibrosis in 56 Nephrectomized Rats via Inhibiting EMT and Wntβ-Catenin Pathway. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150120