The Antioxidative Action of ZTP by Increasing Nrf2ARE Signal Pathway
المؤلفون المشاركون
Yang, Liang
Xu, Bing
Yuan, Chunxu
Dai, Zhi
Wang, Yong
Li, Qiongya
Yang, Qifan
Li, Nuomin
Qing, Hong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
So far, more than 25,000 brain diseases have been shown to be related to oxidative stress.
Excessive free radicals and reactive oxygen species (ROS) can attack cells resulting in dysfunctional proteins, lipids, and nucleic acid, finally leading to imbalance of energy metabolism, cell death, gene mutation, and immune reaction.
Therefore oxidative stress plays an important role in neuronal diseases.
As a traditional Chinese medicine, Zhengtian Pill (ZTP) was reported to have the ability to reduce the blood viscosity of migraine model rats, with increased beta-endorphin, serotonin, adrenaline, and dopamine in brain tissue.
Moreover ZTP can effectively accelerate blood circulation and attenuate blood coagulation.
However, the molecular mechanisms of ZPT are still unclear.
Through the behavioral test we found that ZTP can significantly improve depression-like behavior induced by LPS when rat was treated with ZTP (L 0.17 g/kg, M 0.34 g/kg, and H 0.7 g/kg) intraperitoneal injection once a day for 30 consecutive days.
And ZTP can resist oxidative stress (>72 h) for a longer time.
And ZTP can promote the levels of ATP and SOD and reduce the levels of ROS and MDA in the brain.
At the same time, ZTP can have antioxidant stress through increasing the expression level of Nrf2/HO-1/P38.
These results show that ZTP may be a potential antioxidant stress drug for variety of diseases associated with oxidative stress injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Liang& Xu, Bing& Yuan, Chunxu& Dai, Zhi& Wang, Yong& Li, Qiongya…[et al.]. 2019. The Antioxidative Action of ZTP by Increasing Nrf2ARE Signal Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150144
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Liang…[et al.]. The Antioxidative Action of ZTP by Increasing Nrf2ARE Signal Pathway. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150144
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Liang& Xu, Bing& Yuan, Chunxu& Dai, Zhi& Wang, Yong& Li, Qiongya…[et al.]. The Antioxidative Action of ZTP by Increasing Nrf2ARE Signal Pathway. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150144
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150144
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر