The Antioxidative Action of ZTP by Increasing Nrf2ARE Signal Pathway
Joint Authors
Yang, Liang
Xu, Bing
Yuan, Chunxu
Dai, Zhi
Wang, Yong
Li, Qiongya
Yang, Qifan
Li, Nuomin
Qing, Hong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
So far, more than 25,000 brain diseases have been shown to be related to oxidative stress.
Excessive free radicals and reactive oxygen species (ROS) can attack cells resulting in dysfunctional proteins, lipids, and nucleic acid, finally leading to imbalance of energy metabolism, cell death, gene mutation, and immune reaction.
Therefore oxidative stress plays an important role in neuronal diseases.
As a traditional Chinese medicine, Zhengtian Pill (ZTP) was reported to have the ability to reduce the blood viscosity of migraine model rats, with increased beta-endorphin, serotonin, adrenaline, and dopamine in brain tissue.
Moreover ZTP can effectively accelerate blood circulation and attenuate blood coagulation.
However, the molecular mechanisms of ZPT are still unclear.
Through the behavioral test we found that ZTP can significantly improve depression-like behavior induced by LPS when rat was treated with ZTP (L 0.17 g/kg, M 0.34 g/kg, and H 0.7 g/kg) intraperitoneal injection once a day for 30 consecutive days.
And ZTP can resist oxidative stress (>72 h) for a longer time.
And ZTP can promote the levels of ATP and SOD and reduce the levels of ROS and MDA in the brain.
At the same time, ZTP can have antioxidant stress through increasing the expression level of Nrf2/HO-1/P38.
These results show that ZTP may be a potential antioxidant stress drug for variety of diseases associated with oxidative stress injury.
American Psychological Association (APA)
Yang, Liang& Xu, Bing& Yuan, Chunxu& Dai, Zhi& Wang, Yong& Li, Qiongya…[et al.]. 2019. The Antioxidative Action of ZTP by Increasing Nrf2ARE Signal Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150144
Modern Language Association (MLA)
Yang, Liang…[et al.]. The Antioxidative Action of ZTP by Increasing Nrf2ARE Signal Pathway. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150144
American Medical Association (AMA)
Yang, Liang& Xu, Bing& Yuan, Chunxu& Dai, Zhi& Wang, Yong& Li, Qiongya…[et al.]. The Antioxidative Action of ZTP by Increasing Nrf2ARE Signal Pathway. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150144