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Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF- κ B
المؤلفون المشاركون
Zhong, Hairong
Hong, Choyoung
Han, Zhouxin
Hwang, Seung Jin
Kim, Byunghyun
Xu, Zihang
Lee, Junmun
Hoon Kim, Ki
Jin, Mu Hyun
Zou, Chunpu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-02
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
In oriental medicine, mixtures of medical plants are always used as prescriptions for diseases.
Natural products extracted from herbs have great potential antiaging effects.
Previous studies and clinical trials have shown several critical functions of Erjingwan (EJW), such as nourishing Yin, kidney tonifying and aging-resistance.
We assumed that EJW extracts exerted the antiaging effects through nourishing Yin.
We examined the antiaging effects of EJW extracts on healthy human skin by noninvasive measurements.
Then we estimated the cell proliferation and DPPH radical scavenging rate.
Western blotting analysis was used to determine the expressions of matrix metalloproteinase-1 (MMP-1), type I collagen (COL1A2), p-NF-κB, NF-κB, p-IκBα, IκBα, p-Nrf2, and HO-1.
EJW extracts did not affect moisture content, TEWL and skin chroma, while it significantly improved skin glossiness and skin elasticity.
Moreover, EJW extracts could downregulate the MMP1 expression and upregulate the COL1A2 expression.
In addition, it promoted the Nrf2 pathway while it inhibited the NF-κB pathway.
With the application of cream containing EJW extracts, the skin aging state was significantly improved.
Furthermore, in vitro studies showed that EJW extracts contributed to the repair of skin after injury.
Taken together, the antiaging effects of EJW extracts were related to its antioxidant and anti-inflammatory abilities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhong, Hairong& Hong, Choyoung& Han, Zhouxin& Hwang, Seung Jin& Kim, Byunghyun& Xu, Zihang…[et al.]. 2019. Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF- κ B. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1150311
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhong, Hairong…[et al.]. Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF- κ B. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1150311
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhong, Hairong& Hong, Choyoung& Han, Zhouxin& Hwang, Seung Jin& Kim, Byunghyun& Xu, Zihang…[et al.]. Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF- κ B. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1150311
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150311
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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