Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF- κ B
Joint Authors
Zhong, Hairong
Hong, Choyoung
Han, Zhouxin
Hwang, Seung Jin
Kim, Byunghyun
Xu, Zihang
Lee, Junmun
Hoon Kim, Ki
Jin, Mu Hyun
Zou, Chunpu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
In oriental medicine, mixtures of medical plants are always used as prescriptions for diseases.
Natural products extracted from herbs have great potential antiaging effects.
Previous studies and clinical trials have shown several critical functions of Erjingwan (EJW), such as nourishing Yin, kidney tonifying and aging-resistance.
We assumed that EJW extracts exerted the antiaging effects through nourishing Yin.
We examined the antiaging effects of EJW extracts on healthy human skin by noninvasive measurements.
Then we estimated the cell proliferation and DPPH radical scavenging rate.
Western blotting analysis was used to determine the expressions of matrix metalloproteinase-1 (MMP-1), type I collagen (COL1A2), p-NF-κB, NF-κB, p-IκBα, IκBα, p-Nrf2, and HO-1.
EJW extracts did not affect moisture content, TEWL and skin chroma, while it significantly improved skin glossiness and skin elasticity.
Moreover, EJW extracts could downregulate the MMP1 expression and upregulate the COL1A2 expression.
In addition, it promoted the Nrf2 pathway while it inhibited the NF-κB pathway.
With the application of cream containing EJW extracts, the skin aging state was significantly improved.
Furthermore, in vitro studies showed that EJW extracts contributed to the repair of skin after injury.
Taken together, the antiaging effects of EJW extracts were related to its antioxidant and anti-inflammatory abilities.
American Psychological Association (APA)
Zhong, Hairong& Hong, Choyoung& Han, Zhouxin& Hwang, Seung Jin& Kim, Byunghyun& Xu, Zihang…[et al.]. 2019. Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF- κ B. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1150311
Modern Language Association (MLA)
Zhong, Hairong…[et al.]. Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF- κ B. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1150311
American Medical Association (AMA)
Zhong, Hairong& Hong, Choyoung& Han, Zhouxin& Hwang, Seung Jin& Kim, Byunghyun& Xu, Zihang…[et al.]. Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF- κ B. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1150311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150311