Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1Jagged-2 Signaling Pathway
المؤلفون المشاركون
Su, Minhui
Tian, Fang
Ouyang, Bingchen
Wu, Xiaoyu
Guo, Feng
Chen, Hua
Zhu, Xuejun
Chen, Jianmei
Qian, Xian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-02
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Systemic sclerosis (SSc) is a rare chronic autoimmune disorder, mainly characterized by skin sclerosis.
In this study, Bufei Qingyu Granules (BQG), a Chinese herbal formula, was used to treat SSc.
To better understand the effects and molecular mechanisms of BQG, we successfully established a Bleomycin- (BLM-) induced SSc mouse model, and the mice were treated by BQG.
Meanwhile, transcriptomic and bioinformatics analyses were conducted on those samples.
As a result, we visually showed that BQG ameliorated the overall health of mice, including body weight, spleen, and thymus index.
Thus, it also significantly alleviated inflammation presented by Chemokine (C-X-C motif) ligand 2 (Cxcl2), vasculopathy characterized by α-smooth muscle actin (α-SMA), and fibrotic changes elaborated by not only pathological images, but also the hydroxyproline (HYP) content.
After testing by transcriptomic analysis, Cxcl2, Synaptosomal-associated protein 25 (Snap25), and Eukaryotic translation initiation factor 3, and subunit J2 (Eif3j2) which were differentially expressed genes, were verified, so that the data were credible.
We further found that BQG could regulate Notch signaling pathway by significantly decreasing both mRNA and protein expression levels of Notch-1 and Jagged-2.
Hence, this study demonstrated that BQG could ameliorate the sclerotic skin in mice model involved in inflammation, vascular changes, and fibrosis effects, which was partly mediated by Notch signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Minhui& Tian, Fang& Ouyang, Bingchen& Wu, Xiaoyu& Guo, Feng& Chen, Hua…[et al.]. 2019. Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1Jagged-2 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1150583
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Minhui…[et al.]. Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1Jagged-2 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1150583
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Minhui& Tian, Fang& Ouyang, Bingchen& Wu, Xiaoyu& Guo, Feng& Chen, Hua…[et al.]. Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1Jagged-2 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1150583
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150583
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر