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Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1Jagged-2 Signaling Pathway
Joint Authors
Su, Minhui
Tian, Fang
Ouyang, Bingchen
Wu, Xiaoyu
Guo, Feng
Chen, Hua
Zhu, Xuejun
Chen, Jianmei
Qian, Xian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-02
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Systemic sclerosis (SSc) is a rare chronic autoimmune disorder, mainly characterized by skin sclerosis.
In this study, Bufei Qingyu Granules (BQG), a Chinese herbal formula, was used to treat SSc.
To better understand the effects and molecular mechanisms of BQG, we successfully established a Bleomycin- (BLM-) induced SSc mouse model, and the mice were treated by BQG.
Meanwhile, transcriptomic and bioinformatics analyses were conducted on those samples.
As a result, we visually showed that BQG ameliorated the overall health of mice, including body weight, spleen, and thymus index.
Thus, it also significantly alleviated inflammation presented by Chemokine (C-X-C motif) ligand 2 (Cxcl2), vasculopathy characterized by α-smooth muscle actin (α-SMA), and fibrotic changes elaborated by not only pathological images, but also the hydroxyproline (HYP) content.
After testing by transcriptomic analysis, Cxcl2, Synaptosomal-associated protein 25 (Snap25), and Eukaryotic translation initiation factor 3, and subunit J2 (Eif3j2) which were differentially expressed genes, were verified, so that the data were credible.
We further found that BQG could regulate Notch signaling pathway by significantly decreasing both mRNA and protein expression levels of Notch-1 and Jagged-2.
Hence, this study demonstrated that BQG could ameliorate the sclerotic skin in mice model involved in inflammation, vascular changes, and fibrosis effects, which was partly mediated by Notch signaling pathway.
American Psychological Association (APA)
Su, Minhui& Tian, Fang& Ouyang, Bingchen& Wu, Xiaoyu& Guo, Feng& Chen, Hua…[et al.]. 2019. Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1Jagged-2 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1150583
Modern Language Association (MLA)
Su, Minhui…[et al.]. Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1Jagged-2 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1150583
American Medical Association (AMA)
Su, Minhui& Tian, Fang& Ouyang, Bingchen& Wu, Xiaoyu& Guo, Feng& Chen, Hua…[et al.]. Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1Jagged-2 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1150583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150583