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Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang
المؤلفون المشاركون
Chen, Wei
Hao, Junjie
Zhou, Xiaowei
Li, Ying
Zhang, Mingyu
Gu, Qiong
Liu, Haiyang
Shi, Yafei
Dong, Bin
Zhang, Yuanyuan
Li, Chunyu
Li, Guohui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Nowadays, an increasing number of patients are seriously affected by lung cancer.
Si Jun Zi Tang (SJZ), a four-herb Chinese medicine formula first described approximately one thousand years ago, is often prescribed for cancer patients as a complementary therapy.
But the research on the effective materials for treating cancer using SJZ was rarely reported.
To solve this problem, we evaluate the inhibitory effect of 10 samples of SJZ from different origins on PC9 cells.
Ultraperformance liquid chromatography (UPLC) and hierarchical cluster analysis (HCA) along with canonical correlation analysis (CCA) and bioactivity validation were used to investigate the underlying correlation between the chemical ingredients and the antiproliferative effect of SJZ on PC9 cells.
The evaluation indicated that 10 batches of SJZ could inhibit proliferation of PC9 cells and there was a notable difference in pharmacological activity between the different SJZ samples.
The results of CCA and multivariate statistical analysis indicated that ginsenoside Ro and ginsenoside Rg1 might be active constituents of the antiproliferative effect as determined by spectrum-effect relationships.
The results showed that bioassay and spectrum-effect relationships are suitable to associate sample quality with the active ingredient associated with clinical efficacy.
And our finding would provide foundation and further understanding of the quality evaluation of traditional Chinese medicine decoction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Xiaowei& Li, Ying& Zhang, Mingyu& Hao, Junjie& Gu, Qiong& Liu, Haiyang…[et al.]. 2019. Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150803
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Xiaowei…[et al.]. Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150803
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Xiaowei& Li, Ying& Zhang, Mingyu& Hao, Junjie& Gu, Qiong& Liu, Haiyang…[et al.]. Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150803
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150803
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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