Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang
Joint Authors
Chen, Wei
Hao, Junjie
Zhou, Xiaowei
Li, Ying
Zhang, Mingyu
Gu, Qiong
Liu, Haiyang
Shi, Yafei
Dong, Bin
Zhang, Yuanyuan
Li, Chunyu
Li, Guohui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nowadays, an increasing number of patients are seriously affected by lung cancer.
Si Jun Zi Tang (SJZ), a four-herb Chinese medicine formula first described approximately one thousand years ago, is often prescribed for cancer patients as a complementary therapy.
But the research on the effective materials for treating cancer using SJZ was rarely reported.
To solve this problem, we evaluate the inhibitory effect of 10 samples of SJZ from different origins on PC9 cells.
Ultraperformance liquid chromatography (UPLC) and hierarchical cluster analysis (HCA) along with canonical correlation analysis (CCA) and bioactivity validation were used to investigate the underlying correlation between the chemical ingredients and the antiproliferative effect of SJZ on PC9 cells.
The evaluation indicated that 10 batches of SJZ could inhibit proliferation of PC9 cells and there was a notable difference in pharmacological activity between the different SJZ samples.
The results of CCA and multivariate statistical analysis indicated that ginsenoside Ro and ginsenoside Rg1 might be active constituents of the antiproliferative effect as determined by spectrum-effect relationships.
The results showed that bioassay and spectrum-effect relationships are suitable to associate sample quality with the active ingredient associated with clinical efficacy.
And our finding would provide foundation and further understanding of the quality evaluation of traditional Chinese medicine decoction.
American Psychological Association (APA)
Zhou, Xiaowei& Li, Ying& Zhang, Mingyu& Hao, Junjie& Gu, Qiong& Liu, Haiyang…[et al.]. 2019. Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150803
Modern Language Association (MLA)
Zhou, Xiaowei…[et al.]. Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150803
American Medical Association (AMA)
Zhou, Xiaowei& Li, Ying& Zhang, Mingyu& Hao, Junjie& Gu, Qiong& Liu, Haiyang…[et al.]. Spectrum-Effect Relationship between UPLC Fingerprints and Antilung Cancer Effect of Si Jun Zi Tang. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150803