Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation
المؤلفون المشاركون
Fortis, Spyridon
Lusczek, Elizabeth R.
Weinert, Craig R.
Beilman, Greg J.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-17
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We aimed to investigate whether metabolomic analysis can discriminate acute respiratory failure due to COPD exacerbation from respiratory failure due to heart failure and pneumonia.
Since COPD exacerbation is often overdiagnosed, we focused on those COPD exacerbations that were severe enough to require noninvasive mechanical ventilation.
We enrolled stable COPD subjects and patients with acute respiratory failure requiring noninvasive mechanical ventilation due to COPD, heart failure, and pneumonia.
We excluded subjects with history of both COPD and heart failure and patients with obstructive sleep apnea and obstructive lung disease other than COPD.
We performed metabolomics analysis using NMR.
We constructed partial least squares discriminant analysis (PLS-DA) models to distinguish metabolic profiles.
Serum (p=0.001, R2 = 0.397, Q2 = 0.058) and urine metabolic profiles (p<0.001, R2 = 0.419, Q2 = 0.142) were significantly different between the four diagnosis groups by PLS-DA.
After excluding stable COPD patients, the metabolomes of the various respiratory failure groups did not cluster separately in serum (p=0.2, R2 = 0.631, Q2 = 0.246) or urine (p=0.065, R2 = 0.602, Q2 = −0.134).
However, several metabolites in the serum were reduced in patients with COPD exacerbation and pneumonia.
We did not find a metabolic profile unique to COPD exacerbation, but we were able to clearly and reliably distinguish stable COPD patients from patients with respiratory failure in both serum and urine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fortis, Spyridon& Lusczek, Elizabeth R.& Weinert, Craig R.& Beilman, Greg J.. 2017. Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation. Canadian Respiratory Journal،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1150936
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fortis, Spyridon…[et al.]. Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation. Canadian Respiratory Journal No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1150936
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fortis, Spyridon& Lusczek, Elizabeth R.& Weinert, Craig R.& Beilman, Greg J.. Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation. Canadian Respiratory Journal. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1150936
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150936
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر