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Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation
Joint Authors
Fortis, Spyridon
Lusczek, Elizabeth R.
Weinert, Craig R.
Beilman, Greg J.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We aimed to investigate whether metabolomic analysis can discriminate acute respiratory failure due to COPD exacerbation from respiratory failure due to heart failure and pneumonia.
Since COPD exacerbation is often overdiagnosed, we focused on those COPD exacerbations that were severe enough to require noninvasive mechanical ventilation.
We enrolled stable COPD subjects and patients with acute respiratory failure requiring noninvasive mechanical ventilation due to COPD, heart failure, and pneumonia.
We excluded subjects with history of both COPD and heart failure and patients with obstructive sleep apnea and obstructive lung disease other than COPD.
We performed metabolomics analysis using NMR.
We constructed partial least squares discriminant analysis (PLS-DA) models to distinguish metabolic profiles.
Serum (p=0.001, R2 = 0.397, Q2 = 0.058) and urine metabolic profiles (p<0.001, R2 = 0.419, Q2 = 0.142) were significantly different between the four diagnosis groups by PLS-DA.
After excluding stable COPD patients, the metabolomes of the various respiratory failure groups did not cluster separately in serum (p=0.2, R2 = 0.631, Q2 = 0.246) or urine (p=0.065, R2 = 0.602, Q2 = −0.134).
However, several metabolites in the serum were reduced in patients with COPD exacerbation and pneumonia.
We did not find a metabolic profile unique to COPD exacerbation, but we were able to clearly and reliably distinguish stable COPD patients from patients with respiratory failure in both serum and urine.
American Psychological Association (APA)
Fortis, Spyridon& Lusczek, Elizabeth R.& Weinert, Craig R.& Beilman, Greg J.. 2017. Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation. Canadian Respiratory Journal،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1150936
Modern Language Association (MLA)
Fortis, Spyridon…[et al.]. Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation. Canadian Respiratory Journal No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1150936
American Medical Association (AMA)
Fortis, Spyridon& Lusczek, Elizabeth R.& Weinert, Craig R.& Beilman, Greg J.. Metabolomics in COPD Acute Respiratory Failure Requiring Noninvasive Positive Pressure Ventilation. Canadian Respiratory Journal. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1150936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1150936