Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis
المؤلفون المشاركون
Gan, Dan
Yang, Haojie
Li, Ying
Shen, Sichen
Han, Changpeng
Wu, Jiong
Wang, Zhenyi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-28
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
Objective.
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease whose treatment strategies remain unsatisfactory.
This study aims to investigate the mechanisms of Quyushengxin formula acting on UC based on network pharmacology.
Methods.
Ingredients of the main herbs in Quyushengxin formula were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database.
Absorption, distribution, metabolism, and excretion properties of all ingredients were evaluated for screening out candidate bioactive compounds in Quyushengxin formula.
Weighted ensemble similarity algorithm was applied for predicting direct targets of bioactive ingredients.
Functional enrichment analyses were performed for the targets.
In addition, compound-target network, target-disease network, and target-pathway network were established via Cytoscape 3.6.0 software.
Results.
A total of 41 bioactive compounds in Quyushengxin formula were selected out from the TCMSP database.
These bioactive compounds were predicted to target 94 potential proteins by weighted ensemble similarity algorithm.
Functional analysis suggested these targets were closely related with inflammatory- and immune-related biological progresses.
Furthermore, the results of compound-target network, target-disease network, and target-pathway network indicated that the therapeutic effects of Quyushengxin on UC may be achieved through the synergistic and additive effects.
Conclusion.
Quyushengxin may act on immune and inflammation-related targets to suppress UC progression in a synergistic and additive manner.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Haojie& Li, Ying& Shen, Sichen& Gan, Dan& Han, Changpeng& Wu, Jiong…[et al.]. 2019. Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1151059
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Haojie…[et al.]. Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-22.
https://search.emarefa.net/detail/BIM-1151059
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Haojie& Li, Ying& Shen, Sichen& Gan, Dan& Han, Changpeng& Wu, Jiong…[et al.]. Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1151059
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151059
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر