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Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis
Joint Authors
Gan, Dan
Yang, Haojie
Li, Ying
Shen, Sichen
Han, Changpeng
Wu, Jiong
Wang, Zhenyi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-28
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Objective.
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease whose treatment strategies remain unsatisfactory.
This study aims to investigate the mechanisms of Quyushengxin formula acting on UC based on network pharmacology.
Methods.
Ingredients of the main herbs in Quyushengxin formula were retrieved from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database.
Absorption, distribution, metabolism, and excretion properties of all ingredients were evaluated for screening out candidate bioactive compounds in Quyushengxin formula.
Weighted ensemble similarity algorithm was applied for predicting direct targets of bioactive ingredients.
Functional enrichment analyses were performed for the targets.
In addition, compound-target network, target-disease network, and target-pathway network were established via Cytoscape 3.6.0 software.
Results.
A total of 41 bioactive compounds in Quyushengxin formula were selected out from the TCMSP database.
These bioactive compounds were predicted to target 94 potential proteins by weighted ensemble similarity algorithm.
Functional analysis suggested these targets were closely related with inflammatory- and immune-related biological progresses.
Furthermore, the results of compound-target network, target-disease network, and target-pathway network indicated that the therapeutic effects of Quyushengxin on UC may be achieved through the synergistic and additive effects.
Conclusion.
Quyushengxin may act on immune and inflammation-related targets to suppress UC progression in a synergistic and additive manner.
American Psychological Association (APA)
Yang, Haojie& Li, Ying& Shen, Sichen& Gan, Dan& Han, Changpeng& Wu, Jiong…[et al.]. 2019. Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1151059
Modern Language Association (MLA)
Yang, Haojie…[et al.]. Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-22.
https://search.emarefa.net/detail/BIM-1151059
American Medical Association (AMA)
Yang, Haojie& Li, Ying& Shen, Sichen& Gan, Dan& Han, Changpeng& Wu, Jiong…[et al.]. Network Pharmacology-Based Investigation into the Mechanisms of Quyushengxin Formula for the Treatment of Ulcerative Colitis. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-22.
https://search.emarefa.net/detail/BIM-1151059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151059