Therapeutic Effects of Chinese Herbal Formula (PTQX) on NCNga Mice with Atopic Dermatitis-Like Skin Lesions
المؤلفون المشاركون
Lee, Simon Ming-Yuen
Yan, Fenggen
Chen, Dacan
Zhang, Jing
Li, Xiong
Mo, Xiumei
Liu, Junfeng
Ye, Siqi
Lin, Ying
Qiu, Xiaohui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Atopic dermatitis (AD), also known as atopic eczema, is a chronic pruritic inflammatory skin disease.
The available systemic therapies for atopic dermatitis are inadequate.
Objective.
This study aimed to evaluate the effects of the Chinese herbal formula Pei Tu Qing Xin (PTQX) on dermatitis severity and ear swelling, immunomodulation, and the infiltration of mast cells in a mouse model of 1-chloro-2,4-dinitrobenzene- (DNCB-) induced AD.
Methods.
AD-like symptoms were induced by DNCB in NC/Nga mice.
Skin lesions, dermatitis, ear swelling, and scratching behaviour were evaluated.
Changes in the T-helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) subtypes and immunoregulation in the spleen and lymph nodes were detected by flow cytometry.
Results.
Histopathological and immunohistochemical analyses demonstrated that PTQX decreased the DNCB-mediated induction of mast cells and infiltration of inflammatory cells in the ear and dorsal skin.
PTQX also reduced the DNCB-induced increase in the serum immunoglobulin E level, pruritus, and dermatitis (red, flaky areas) on the dorsal skin.
Furthermore, PTQX regulated the balance between the populations of Th1, Th2, Th17, and Treg cells (particularly the latter two) in the lymph nodes.
Conclusions.
Our results suggest that the Chinese herbal formula PTQX can alleviate symptoms of AD, such as epithelial damage, redness, swelling, and pruritus, and potentially be used to treat this condition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yan, Fenggen& Zhang, Jing& Li, Xiong& Mo, Xiumei& Liu, Junfeng& Ye, Siqi…[et al.]. 2019. Therapeutic Effects of Chinese Herbal Formula (PTQX) on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151229
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yan, Fenggen…[et al.]. Therapeutic Effects of Chinese Herbal Formula (PTQX) on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1151229
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yan, Fenggen& Zhang, Jing& Li, Xiong& Mo, Xiumei& Liu, Junfeng& Ye, Siqi…[et al.]. Therapeutic Effects of Chinese Herbal Formula (PTQX) on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151229
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151229
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر