Therapeutic Effects of Chinese Herbal Formula (PTQX) on NCNga Mice with Atopic Dermatitis-Like Skin Lesions
Joint Authors
Lee, Simon Ming-Yuen
Yan, Fenggen
Chen, Dacan
Zhang, Jing
Li, Xiong
Mo, Xiumei
Liu, Junfeng
Ye, Siqi
Lin, Ying
Qiu, Xiaohui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Atopic dermatitis (AD), also known as atopic eczema, is a chronic pruritic inflammatory skin disease.
The available systemic therapies for atopic dermatitis are inadequate.
Objective.
This study aimed to evaluate the effects of the Chinese herbal formula Pei Tu Qing Xin (PTQX) on dermatitis severity and ear swelling, immunomodulation, and the infiltration of mast cells in a mouse model of 1-chloro-2,4-dinitrobenzene- (DNCB-) induced AD.
Methods.
AD-like symptoms were induced by DNCB in NC/Nga mice.
Skin lesions, dermatitis, ear swelling, and scratching behaviour were evaluated.
Changes in the T-helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) subtypes and immunoregulation in the spleen and lymph nodes were detected by flow cytometry.
Results.
Histopathological and immunohistochemical analyses demonstrated that PTQX decreased the DNCB-mediated induction of mast cells and infiltration of inflammatory cells in the ear and dorsal skin.
PTQX also reduced the DNCB-induced increase in the serum immunoglobulin E level, pruritus, and dermatitis (red, flaky areas) on the dorsal skin.
Furthermore, PTQX regulated the balance between the populations of Th1, Th2, Th17, and Treg cells (particularly the latter two) in the lymph nodes.
Conclusions.
Our results suggest that the Chinese herbal formula PTQX can alleviate symptoms of AD, such as epithelial damage, redness, swelling, and pruritus, and potentially be used to treat this condition.
American Psychological Association (APA)
Yan, Fenggen& Zhang, Jing& Li, Xiong& Mo, Xiumei& Liu, Junfeng& Ye, Siqi…[et al.]. 2019. Therapeutic Effects of Chinese Herbal Formula (PTQX) on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151229
Modern Language Association (MLA)
Yan, Fenggen…[et al.]. Therapeutic Effects of Chinese Herbal Formula (PTQX) on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1151229
American Medical Association (AMA)
Yan, Fenggen& Zhang, Jing& Li, Xiong& Mo, Xiumei& Liu, Junfeng& Ye, Siqi…[et al.]. Therapeutic Effects of Chinese Herbal Formula (PTQX) on NCNga Mice with Atopic Dermatitis-Like Skin Lesions. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151229