Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models
المؤلفون المشاركون
Lim, Eun Yeong
Kim, Yun Tai
Kim, Jae Goo
Lee, Jaekwang
Lee, Changho
Shim, Jaewon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cnidium officinale, widely cultivated in East Asia, has been reported to exhibit pharmacological efficacy in various disorders.
However, little has been reported on its role as a pain killer.
In this study, we reveal that the C.
officinale extract (COE) has great efficacy as a novel analgesic in various in vivo pain models.
Administration of COE attenuated hypersensitivity in all postoperative, neuropathic, and menopausal pain models.
Decreased hyperalgesia was confirmed by a mechanical withdrawal threshold assay and ultrasonic vocalization call analysis.
In addition, application of COE inhibited the induction of the proinflammatory cytokines and calpain-3 on dorsal root ganglion neurons in a spared nerve injury rat model.
Treatment with ferulic acid, which was identified as one of the components of COE by HPLC analysis, alleviated nociceptive behaviors.
Our findings suggest that ferulic acid is an active compound from COE, and COE is a potential phytomedical source for pain relief by inhibiting the process of inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Eun Yeong& Kim, Jae Goo& Lee, Jaekwang& Lee, Changho& Shim, Jaewon& Kim, Yun Tai. 2019. Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Eun Yeong…[et al.]. Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1151869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Eun Yeong& Kim, Jae Goo& Lee, Jaekwang& Lee, Changho& Shim, Jaewon& Kim, Yun Tai. Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر