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Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models
Joint Authors
Lim, Eun Yeong
Kim, Yun Tai
Kim, Jae Goo
Lee, Jaekwang
Lee, Changho
Shim, Jaewon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cnidium officinale, widely cultivated in East Asia, has been reported to exhibit pharmacological efficacy in various disorders.
However, little has been reported on its role as a pain killer.
In this study, we reveal that the C.
officinale extract (COE) has great efficacy as a novel analgesic in various in vivo pain models.
Administration of COE attenuated hypersensitivity in all postoperative, neuropathic, and menopausal pain models.
Decreased hyperalgesia was confirmed by a mechanical withdrawal threshold assay and ultrasonic vocalization call analysis.
In addition, application of COE inhibited the induction of the proinflammatory cytokines and calpain-3 on dorsal root ganglion neurons in a spared nerve injury rat model.
Treatment with ferulic acid, which was identified as one of the components of COE by HPLC analysis, alleviated nociceptive behaviors.
Our findings suggest that ferulic acid is an active compound from COE, and COE is a potential phytomedical source for pain relief by inhibiting the process of inflammation.
American Psychological Association (APA)
Lim, Eun Yeong& Kim, Jae Goo& Lee, Jaekwang& Lee, Changho& Shim, Jaewon& Kim, Yun Tai. 2019. Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151869
Modern Language Association (MLA)
Lim, Eun Yeong…[et al.]. Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1151869
American Medical Association (AMA)
Lim, Eun Yeong& Kim, Jae Goo& Lee, Jaekwang& Lee, Changho& Shim, Jaewon& Kim, Yun Tai. Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151869
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151869