Protective Effects of Angong Niuhuang Pill on Early Atherosclerosis in ApoE-- Mice by Reducing the Inflammatory Response
المؤلفون المشاركون
Chai, Yushuang
Yin, Zhen
Fan, Qinghong
Zhang, Zhe
Ye, Kaihe
Xu, Yimin
Xiao, Wei
Chai, Xiaomeng
Zhu, Tao
Nie, Hong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Atherosclerosis (AS) is the primary cause of cardiocerebrovascular disease, and inflammation is responsible for the initiation of its pathogenesis.
Therefore, targeting inflammatory pathways to prevent AS progression is an ideal strategy.
Angong Niuhuang pill (ANP) is a well-known traditional Chinese medicine and has been widely used for thousands of years to treat central nervous system and cardiovascular diseases.
In this study, we investigated the role of ANP in reducing inflammation during early AS, using a high-fat diet-induced ApoE−/− mouse model of AS.
Compared to those with simvastatin, ANP had no significant effect on serum triglyceride, low-density lipoprotein, and high-density lipoprotein levels.
However, it effectively inhibited splenic and vascular inflammation.
This agent also reduced the Th17/CD4+T ratio and mRNA expression of IL-6 and increased the Treg/CD4+T ratio and mRNA expression of TGF-β1.
Thus, ANP restored Th17/Treg homeostasis in the spleen.
It also regulated pro- and anti-inflammatory cytokine expression in the aorta in a similar manner.
Further, it downregulated the expression of chemokine receptors (CCR2, CXCR3), their ligands (MCP-1, MCP-2, and MCP-3), and cell adhesion molecules (VCAM-1, ICAM-1) in arterial vessels.
These results indicate that ANP can ameliorate the development of early AS, mainly by reducing inflammation instead of acting as an antihyperlipidemic drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chai, Yushuang& Yin, Zhen& Fan, Qinghong& Zhang, Zhe& Ye, Kaihe& Xu, Yimin…[et al.]. 2019. Protective Effects of Angong Niuhuang Pill on Early Atherosclerosis in ApoE-- Mice by Reducing the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151916
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chai, Yushuang…[et al.]. Protective Effects of Angong Niuhuang Pill on Early Atherosclerosis in ApoE-- Mice by Reducing the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1151916
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chai, Yushuang& Yin, Zhen& Fan, Qinghong& Zhang, Zhe& Ye, Kaihe& Xu, Yimin…[et al.]. Protective Effects of Angong Niuhuang Pill on Early Atherosclerosis in ApoE-- Mice by Reducing the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151916
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151916
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر