Protective Effects of Angong Niuhuang Pill on Early Atherosclerosis in ApoE-- Mice by Reducing the Inflammatory Response
Joint Authors
Chai, Yushuang
Yin, Zhen
Fan, Qinghong
Zhang, Zhe
Ye, Kaihe
Xu, Yimin
Xiao, Wei
Chai, Xiaomeng
Zhu, Tao
Nie, Hong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Atherosclerosis (AS) is the primary cause of cardiocerebrovascular disease, and inflammation is responsible for the initiation of its pathogenesis.
Therefore, targeting inflammatory pathways to prevent AS progression is an ideal strategy.
Angong Niuhuang pill (ANP) is a well-known traditional Chinese medicine and has been widely used for thousands of years to treat central nervous system and cardiovascular diseases.
In this study, we investigated the role of ANP in reducing inflammation during early AS, using a high-fat diet-induced ApoE−/− mouse model of AS.
Compared to those with simvastatin, ANP had no significant effect on serum triglyceride, low-density lipoprotein, and high-density lipoprotein levels.
However, it effectively inhibited splenic and vascular inflammation.
This agent also reduced the Th17/CD4+T ratio and mRNA expression of IL-6 and increased the Treg/CD4+T ratio and mRNA expression of TGF-β1.
Thus, ANP restored Th17/Treg homeostasis in the spleen.
It also regulated pro- and anti-inflammatory cytokine expression in the aorta in a similar manner.
Further, it downregulated the expression of chemokine receptors (CCR2, CXCR3), their ligands (MCP-1, MCP-2, and MCP-3), and cell adhesion molecules (VCAM-1, ICAM-1) in arterial vessels.
These results indicate that ANP can ameliorate the development of early AS, mainly by reducing inflammation instead of acting as an antihyperlipidemic drug.
American Psychological Association (APA)
Chai, Yushuang& Yin, Zhen& Fan, Qinghong& Zhang, Zhe& Ye, Kaihe& Xu, Yimin…[et al.]. 2019. Protective Effects of Angong Niuhuang Pill on Early Atherosclerosis in ApoE-- Mice by Reducing the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151916
Modern Language Association (MLA)
Chai, Yushuang…[et al.]. Protective Effects of Angong Niuhuang Pill on Early Atherosclerosis in ApoE-- Mice by Reducing the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1151916
American Medical Association (AMA)
Chai, Yushuang& Yin, Zhen& Fan, Qinghong& Zhang, Zhe& Ye, Kaihe& Xu, Yimin…[et al.]. Protective Effects of Angong Niuhuang Pill on Early Atherosclerosis in ApoE-- Mice by Reducing the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1151916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151916