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Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr
المؤلفون المشاركون
Wei, Fenfen
He, Qinghua
Wang, Wenjuan
Pei, Dong
Zhang, Bo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Cynomorium songaricum Rupr, known as Suo Yang, is most commonly used to treat fatigue, protect the liver, and invigorate kidneys in Northwest China.
Given the wide medicinal utilisation and lack of safety evaluation, this work evaluated the acute toxicity, genetic toxicity, and 90-day repeated oral toxicity of Suo Yang.
Twenty Kunming mice were orally given Suo Yang once and observed for 14 days in the acute toxicity test.
The genetic toxicity of Suo Yang was tested using in vivo and vitro assays (bacterial reverse mutation test, mouse bone marrow micronucleus assay, and spermatocyte chromosomal aberration assay).
In the 90-day repeated oral toxicity study, 80 SD rats were randomly divided into 4 groups and then orally given Suo Yang at different concentrations (1.04, 2.08 or 4.16 g/kg), while the control group was given sterile water.
In the acute toxicity test, no abnormal behaviour or mortality was found in mice.
The results suggest that the maximum tolerable dose of Suo Yang is greater than 15 g/kg.
In the genotoxicity studies, no revertant colonies were produced in vitro.
In the in vivo assays, no increased frequencies of micronuclei or structural abnormalities of spermatocyte chromosomes were found.
In the 90-day repeated oral toxicity study, no significant toxicological manifestations were observed in haematological parameters or clinical and pathological examinations.
In summary, these results suggest that Suo Yang at the given doses does not cause adverse effects in animals.
Thus, Suo Yang can reasonably be considered a safe herbal medicine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wei, Fenfen& He, Qinghua& Wang, Wenjuan& Pei, Dong& Zhang, Bo. 2019. Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151952
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wei, Fenfen…[et al.]. Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1151952
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wei, Fenfen& He, Qinghua& Wang, Wenjuan& Pei, Dong& Zhang, Bo. Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151952
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151952
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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