Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula
المؤلفون المشاركون
Chen, Xuetong
Su, Xing
Jiang, Meng
Li, Yueping
Zhu, Jinglin
Zheng, Chunli
Zhou, Jun
Xiao, Wei
Li, Yan
Wang, Yonghua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-26
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Lung cancer is the most common cause of cancer death with high morbidity and mortality, which non-small-cell lung cancer (NSCLC) accounting for the majority.
Traditional Chinese Medicine (TCM) is effective in the treatment of complex diseases, especially cancer.
However, TCM is still in the conceptual stage.
The interaction between different components remains unknown due to its multicomponent and multitarget characteristics.
In this study, compound Liuju formula was taken as an example to isolate compounds with synergistic biological activity through systems pharmacology strategy.
Through pharmacokinetic evaluation, 37 potentially active compounds were screened out.
Meanwhile, 116 targets of these compounds were obtained by combing with the target prediction model.
Through network analysis, we found that multicomponent drugs can present a synergistic effect through regulating inflammatory signaling pathway, invasion pathway, proliferation, and apoptosis pathway.
Finally, it was confirmed that the bioactive compounds of compound Liuju formula have not only a killing effect on NSCLC tumor cells but also a synergistic effect on inhibiting the secretion of correlative inflammatory mediators, including TNF-α and IL-1β.
The systems pharmacology method was applied in this study, which provides a new direction for analyzing the mechanism of TCM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Xing& Jiang, Meng& Li, Yueping& Zhu, Jinglin& Zheng, Chunli& Chen, Xuetong…[et al.]. 2019. Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1151980
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Xing…[et al.]. Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1151980
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Xing& Jiang, Meng& Li, Yueping& Zhu, Jinglin& Zheng, Chunli& Chen, Xuetong…[et al.]. Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1151980
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151980
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر