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Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula
Joint Authors
Chen, Xuetong
Su, Xing
Jiang, Meng
Li, Yueping
Zhu, Jinglin
Zheng, Chunli
Zhou, Jun
Xiao, Wei
Li, Yan
Wang, Yonghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-26
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Lung cancer is the most common cause of cancer death with high morbidity and mortality, which non-small-cell lung cancer (NSCLC) accounting for the majority.
Traditional Chinese Medicine (TCM) is effective in the treatment of complex diseases, especially cancer.
However, TCM is still in the conceptual stage.
The interaction between different components remains unknown due to its multicomponent and multitarget characteristics.
In this study, compound Liuju formula was taken as an example to isolate compounds with synergistic biological activity through systems pharmacology strategy.
Through pharmacokinetic evaluation, 37 potentially active compounds were screened out.
Meanwhile, 116 targets of these compounds were obtained by combing with the target prediction model.
Through network analysis, we found that multicomponent drugs can present a synergistic effect through regulating inflammatory signaling pathway, invasion pathway, proliferation, and apoptosis pathway.
Finally, it was confirmed that the bioactive compounds of compound Liuju formula have not only a killing effect on NSCLC tumor cells but also a synergistic effect on inhibiting the secretion of correlative inflammatory mediators, including TNF-α and IL-1β.
The systems pharmacology method was applied in this study, which provides a new direction for analyzing the mechanism of TCM.
American Psychological Association (APA)
Su, Xing& Jiang, Meng& Li, Yueping& Zhu, Jinglin& Zheng, Chunli& Chen, Xuetong…[et al.]. 2019. Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1151980
Modern Language Association (MLA)
Su, Xing…[et al.]. Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1151980
American Medical Association (AMA)
Su, Xing& Jiang, Meng& Li, Yueping& Zhu, Jinglin& Zheng, Chunli& Chen, Xuetong…[et al.]. Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1151980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151980