Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease
المؤلفون المشاركون
Wang, Deguo
Wu, Yong
Wang, Ancai
Chen, Yueyun
Zhang, Ting
Hu, Nengwei
المصدر
Cardiology Research and Practice
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
Donepezil, a widely used cholinesterase inhibitor for treating Alzheimer’s disease, has been reported to induce bradyarrhythmias and torsade de pointes.
In this study, we aimed at determining electrocardiogram changes of donepezil administration in elderly patients with ischemic heart disease, who tend to suffer from cognitive disorders.
Methods.
Sixty patients with ischemic heart disease and mild cognitive impairment were treated with donepezil (5 mg/day) and followed up for at least four weeks.
A twenty-four-hour ambulatory electrocardiogram was performed for the analysis of heart rate variability.
The ECG parameters including heart rate (HR), PR and RR intervals, QT interval, and QRS duration were recorded at the baseline and after donepezil administration.
Results.
Donepezil administration resulted in significant reduction in mean HR and the lowest HR and prolongation of PR and RR intervals, whereas it had no significant effects on QRS duration and QT parameters including QT, corrected QT interval, QT dispersion, and Tpeak-end interval.
HRV analysis showed that donepezil administration significantly improved parasympathetic function, indicated by decreased low/high frequency (LF/HF) ratio and high frequency (HF) components and oscillation of RR intervals.
Conclusions.
These data demonstrated that donepezil administration decreased HR, prolonged PR interval, and increased parasympathetic function without affecting QRS duration and QT intervals, suggesting that it can be used safely in elderly patients with ischemic heart disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Deguo& Wu, Yong& Wang, Ancai& Chen, Yueyun& Zhang, Ting& Hu, Nengwei. 2018. Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1152122
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Deguo…[et al.]. Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease. Cardiology Research and Practice No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1152122
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Deguo& Wu, Yong& Wang, Ancai& Chen, Yueyun& Zhang, Ting& Hu, Nengwei. Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1152122
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152122
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر