Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease
Joint Authors
Wang, Deguo
Wu, Yong
Wang, Ancai
Chen, Yueyun
Zhang, Ting
Hu, Nengwei
Source
Cardiology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
Donepezil, a widely used cholinesterase inhibitor for treating Alzheimer’s disease, has been reported to induce bradyarrhythmias and torsade de pointes.
In this study, we aimed at determining electrocardiogram changes of donepezil administration in elderly patients with ischemic heart disease, who tend to suffer from cognitive disorders.
Methods.
Sixty patients with ischemic heart disease and mild cognitive impairment were treated with donepezil (5 mg/day) and followed up for at least four weeks.
A twenty-four-hour ambulatory electrocardiogram was performed for the analysis of heart rate variability.
The ECG parameters including heart rate (HR), PR and RR intervals, QT interval, and QRS duration were recorded at the baseline and after donepezil administration.
Results.
Donepezil administration resulted in significant reduction in mean HR and the lowest HR and prolongation of PR and RR intervals, whereas it had no significant effects on QRS duration and QT parameters including QT, corrected QT interval, QT dispersion, and Tpeak-end interval.
HRV analysis showed that donepezil administration significantly improved parasympathetic function, indicated by decreased low/high frequency (LF/HF) ratio and high frequency (HF) components and oscillation of RR intervals.
Conclusions.
These data demonstrated that donepezil administration decreased HR, prolonged PR interval, and increased parasympathetic function without affecting QRS duration and QT intervals, suggesting that it can be used safely in elderly patients with ischemic heart disease.
American Psychological Association (APA)
Wang, Deguo& Wu, Yong& Wang, Ancai& Chen, Yueyun& Zhang, Ting& Hu, Nengwei. 2018. Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease. Cardiology Research and Practice،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1152122
Modern Language Association (MLA)
Wang, Deguo…[et al.]. Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease. Cardiology Research and Practice No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1152122
American Medical Association (AMA)
Wang, Deguo& Wu, Yong& Wang, Ancai& Chen, Yueyun& Zhang, Ting& Hu, Nengwei. Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease. Cardiology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1152122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152122