Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation
المؤلفون المشاركون
Zhang, Tao
Liu, Yuan
Peng, Xu
Fan, Junwei
Peng, Zhihai
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the association of donor and recipient IL-15 genetic variants with HCC recurrence and prognosis after LT.
Methods.
A total of 112 liver transplant patients with HBV-related HCC were enrolled.
IL-15 rs10519613 and rs13122930 were genotyped in donors and recipients.
Results.
Recipient IL-15 rs10519613 polymorphism was found to be significantly related to HCC recurrence after LT.
In multivariate analysis, tumor thrombus, UCSF criteria, and recipient IL-15 rs10519613 genotypes were independent predictive factors of HCC recurrence after LT.
Kaplan-Meier survival analysis demonstrated that patients with recipient IL-15 rs10519613 CA/AA genotypes had a decreased disease-free survival and overall survival than those with the CC genotype.
Recipient IL-15 rs10519613 genetic variant could improve survival prediction when combined with the UCSF criteria.
Furthermore, Cox proportional hazard regression analysis revealed that tumor size (p=0.012, p=0.623), tumor thrombus (p=0.011, p=0.015), UCSF criteria (p=0.471, p=0.013), and recipient IL-15 rs10519613 genotype (p=0.039, p=0.008) were independent factors of predicting DFS and OS.
Conclusions.
Recipient IL-15 rs10519613 polymorphism was associated with HCC recurrence after LT and might be a potential genetic marker for the clinical outcome of HCC patients treated with LT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Tao& Liu, Yuan& Peng, Xu& Fan, Junwei& Peng, Zhihai. 2017. Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152206
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Tao…[et al.]. Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152206
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Tao& Liu, Yuan& Peng, Xu& Fan, Junwei& Peng, Zhihai. Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152206
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152206
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر