Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation
Joint Authors
Zhang, Tao
Liu, Yuan
Peng, Xu
Fan, Junwei
Peng, Zhihai
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To investigate the association of donor and recipient IL-15 genetic variants with HCC recurrence and prognosis after LT.
Methods.
A total of 112 liver transplant patients with HBV-related HCC were enrolled.
IL-15 rs10519613 and rs13122930 were genotyped in donors and recipients.
Results.
Recipient IL-15 rs10519613 polymorphism was found to be significantly related to HCC recurrence after LT.
In multivariate analysis, tumor thrombus, UCSF criteria, and recipient IL-15 rs10519613 genotypes were independent predictive factors of HCC recurrence after LT.
Kaplan-Meier survival analysis demonstrated that patients with recipient IL-15 rs10519613 CA/AA genotypes had a decreased disease-free survival and overall survival than those with the CC genotype.
Recipient IL-15 rs10519613 genetic variant could improve survival prediction when combined with the UCSF criteria.
Furthermore, Cox proportional hazard regression analysis revealed that tumor size (p=0.012, p=0.623), tumor thrombus (p=0.011, p=0.015), UCSF criteria (p=0.471, p=0.013), and recipient IL-15 rs10519613 genotype (p=0.039, p=0.008) were independent factors of predicting DFS and OS.
Conclusions.
Recipient IL-15 rs10519613 polymorphism was associated with HCC recurrence after LT and might be a potential genetic marker for the clinical outcome of HCC patients treated with LT.
American Psychological Association (APA)
Zhang, Tao& Liu, Yuan& Peng, Xu& Fan, Junwei& Peng, Zhihai. 2017. Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152206
Modern Language Association (MLA)
Zhang, Tao…[et al.]. Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152206
American Medical Association (AMA)
Zhang, Tao& Liu, Yuan& Peng, Xu& Fan, Junwei& Peng, Zhihai. Association between Recipient IL-15 Genetic Variant and the Prognosis of HBV-Related Hepatocellular Carcinoma after Liver Transplantation. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152206