Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study
المؤلفون المشاركون
Andabak Rogulj, Ana
Alajbeg, Iva Z.
Lapić, Ivana
Rogić, Dunja
Vuletić, Lea
Illeš, Davor
Knezović Zlatarić, Dubravka
Badel, Tomislav
Vrbanović, Ema
Alajbeg, Ivan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals.
Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days.
Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (TAC), and uric acid (UA) were analyzed using spectrophotometric methods, while 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA) were determined using immunoassays.
No significant differences for salivary OS markers between men and women were observed.
For all examined OS markers, no significant day-to-day variations were demonstrated.
Significant diurnal variations were found in salivary GPX, TAC and MDA levels.
For SOD, TAC, GPX, and UA, good-to-moderate intraindividual coefficients of variations (CVs) were observed in more than 75% of the subjects.
For MDA and 8-OHdG, intraindividual CVs > 35% were observed in 60% and 40% of the subjects, respectively.
Between-subject variance was wide for all examined OS markers (CV% 30.08%–85.70%).
Due to high intraindividual variability in the salivary concentrations of MDA and 8-OHdG, those markers cannot be reliably verified based on single measurements and multiple measurements over several days would provide more reliable information.
Salivary SOD, TAC, GPX, and UA proved stable across three days of measurement.
Trial Registration.
ClinicalTrials.gov NCT03029494.
Registered on 2017-01-19.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alajbeg, Iva Z.& Lapić, Ivana& Rogić, Dunja& Vuletić, Lea& Andabak Rogulj, Ana& Illeš, Davor…[et al.]. 2017. Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study. Disease Markers،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152253
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alajbeg, Iva Z.…[et al.]. Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study. Disease Markers No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1152253
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alajbeg, Iva Z.& Lapić, Ivana& Rogić, Dunja& Vuletić, Lea& Andabak Rogulj, Ana& Illeš, Davor…[et al.]. Within-Subject Reliability and between-Subject Variability of Oxidative Stress Markers in Saliva of Healthy Subjects: A Longitudinal Pilot Study. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152253
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152253
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر