DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer
المؤلفون المشاركون
Jin, Hongchuan
Cheng, Yuen
Williams, Marissa
Chu, Wai Kit
Leygo, Catherine
Chan, Michael W. Y.
Grusch, Michael
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-05
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an important priority for assigning optimal treatment for each individual with suspected illness.
Biomarkers are crucial in the screening of patients with a high risk of developing cancer, diagnosing patients with suspicious tumours at the earliest possible stage, establishing an accurate prognosis, and predicting and monitoring the response to specific therapies.
Epigenetic alterations are innovative biomarkers for cancer, due to their stability, frequency, and noninvasive accessibility in bodily fluids.
Epigenetic modifications are also reversible and potentially useful as therapeutic targets.
Despite this, there is still a lack of accurate biomarkers for the conclusive diagnosis of most cancer types; thus, there is a strong need for continued investigation to expand this area of research.
In this review, we summarise current knowledge on methylated DNA and its implications in cancer to explore its potential as an epigenetic biomarker to be translated for clinical application.
We propose that the identification of biomarkers with higher accuracy and more effective detection methods will enable improved clinical management of patients and the intervention at early-stage disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leygo, Catherine& Williams, Marissa& Jin, Hongchuan& Chan, Michael W. Y.& Chu, Wai Kit& Grusch, Michael…[et al.]. 2017. DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer. Disease Markers،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1152299
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leygo, Catherine…[et al.]. DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer. Disease Markers No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1152299
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leygo, Catherine& Williams, Marissa& Jin, Hongchuan& Chan, Michael W. Y.& Chu, Wai Kit& Grusch, Michael…[et al.]. DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1152299
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152299
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر