DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer
Joint Authors
Jin, Hongchuan
Cheng, Yuen
Williams, Marissa
Chu, Wai Kit
Leygo, Catherine
Chan, Michael W. Y.
Grusch, Michael
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an important priority for assigning optimal treatment for each individual with suspected illness.
Biomarkers are crucial in the screening of patients with a high risk of developing cancer, diagnosing patients with suspicious tumours at the earliest possible stage, establishing an accurate prognosis, and predicting and monitoring the response to specific therapies.
Epigenetic alterations are innovative biomarkers for cancer, due to their stability, frequency, and noninvasive accessibility in bodily fluids.
Epigenetic modifications are also reversible and potentially useful as therapeutic targets.
Despite this, there is still a lack of accurate biomarkers for the conclusive diagnosis of most cancer types; thus, there is a strong need for continued investigation to expand this area of research.
In this review, we summarise current knowledge on methylated DNA and its implications in cancer to explore its potential as an epigenetic biomarker to be translated for clinical application.
We propose that the identification of biomarkers with higher accuracy and more effective detection methods will enable improved clinical management of patients and the intervention at early-stage disease.
American Psychological Association (APA)
Leygo, Catherine& Williams, Marissa& Jin, Hongchuan& Chan, Michael W. Y.& Chu, Wai Kit& Grusch, Michael…[et al.]. 2017. DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer. Disease Markers،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1152299
Modern Language Association (MLA)
Leygo, Catherine…[et al.]. DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer. Disease Markers No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1152299
American Medical Association (AMA)
Leygo, Catherine& Williams, Marissa& Jin, Hongchuan& Chan, Michael W. Y.& Chu, Wai Kit& Grusch, Michael…[et al.]. DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1152299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152299