Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population
المؤلفون المشاركون
Zhou, Bin
Chen, Nan
Song, Huizi
Peng, Ying
Xie, Xiaochuan
Dou, Qingyu
Zhong, Yue
Rao, Li
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
To explore the role of Interkeulin-31 (IL-31) in dilated cardiomyopathy (DCM), in our study, two SNPs of IL-31, rs4758680 (C/A) and rs7977932 (C/G), were analyzed in 331 DCM patients and 493 controls in a Chinese Han population.
The frequencies of C allele and CC genotype of rs4758680 were significantly increased in DCM patients (P=0.005, P=0.001, resp.).
Compared to CC genotype of rs4758680, the A carriers (CA/AA genotypes) were the protect factors in DCM susceptibility while the frequencies of CA/AA genotypes were decreased in the dominant model for DCM group (P<0.001, OR = 0.56, 95%CI = 0.39–0.79).
Moreover, IL-31 mRNA expression level of white blood cells was increased in DCM patients (0.072 (0.044–0.144) versus 0.036 (0.020–0.052), P<0.001).
In survival analysis of 159 DCM patients, Kaplan-Meier curve revealed the correlation between CC homozygote of rs4758680 and worse prognosis for DCM group (P=0.005).
Compared to CC genotype, the CA/AA genotypes were the independent factors in both univariate (HR = 0.530, 95%CI = 0.337–0.834, P=0.006) and multivariate analyses after age, gender, left ventricular end-diastolic diameter, and left ventricular ejection fraction adjusted (HR = 0.548, 95%CI = 0.345–0.869, P=0.011).
Thus, we concluded that IL-31 gene polymorphisms were tightly associated with DCM susceptibility and contributed to worse prognosis in DCM patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Huizi& Peng, Ying& Zhou, Bin& Chen, Nan& Xie, Xiaochuan& Dou, Qingyu…[et al.]. 2017. Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152319
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Huizi…[et al.]. Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152319
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Huizi& Peng, Ying& Zhou, Bin& Chen, Nan& Xie, Xiaochuan& Dou, Qingyu…[et al.]. Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152319
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152319
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر