Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population
Joint Authors
Zhou, Bin
Chen, Nan
Song, Huizi
Peng, Ying
Xie, Xiaochuan
Dou, Qingyu
Zhong, Yue
Rao, Li
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To explore the role of Interkeulin-31 (IL-31) in dilated cardiomyopathy (DCM), in our study, two SNPs of IL-31, rs4758680 (C/A) and rs7977932 (C/G), were analyzed in 331 DCM patients and 493 controls in a Chinese Han population.
The frequencies of C allele and CC genotype of rs4758680 were significantly increased in DCM patients (P=0.005, P=0.001, resp.).
Compared to CC genotype of rs4758680, the A carriers (CA/AA genotypes) were the protect factors in DCM susceptibility while the frequencies of CA/AA genotypes were decreased in the dominant model for DCM group (P<0.001, OR = 0.56, 95%CI = 0.39–0.79).
Moreover, IL-31 mRNA expression level of white blood cells was increased in DCM patients (0.072 (0.044–0.144) versus 0.036 (0.020–0.052), P<0.001).
In survival analysis of 159 DCM patients, Kaplan-Meier curve revealed the correlation between CC homozygote of rs4758680 and worse prognosis for DCM group (P=0.005).
Compared to CC genotype, the CA/AA genotypes were the independent factors in both univariate (HR = 0.530, 95%CI = 0.337–0.834, P=0.006) and multivariate analyses after age, gender, left ventricular end-diastolic diameter, and left ventricular ejection fraction adjusted (HR = 0.548, 95%CI = 0.345–0.869, P=0.011).
Thus, we concluded that IL-31 gene polymorphisms were tightly associated with DCM susceptibility and contributed to worse prognosis in DCM patients.
American Psychological Association (APA)
Song, Huizi& Peng, Ying& Zhou, Bin& Chen, Nan& Xie, Xiaochuan& Dou, Qingyu…[et al.]. 2017. Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population. Disease Markers،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152319
Modern Language Association (MLA)
Song, Huizi…[et al.]. Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population. Disease Markers No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1152319
American Medical Association (AMA)
Song, Huizi& Peng, Ying& Zhou, Bin& Chen, Nan& Xie, Xiaochuan& Dou, Qingyu…[et al.]. Associations between Interleukin-31 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Population. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1152319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152319