Association of GCLM -588CT and GCLC -129TC Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population
المؤلفون المشاركون
Perfilyeva, Anastassiya V.
Skvortsova, Liliya A.
Djansugurova, Leyla B.
Khussainova, Elmira
Mansharipova, Alma
Forman, Henry Jay
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Glutamate cysteine ligase (GCL) is a rate-limiting enzyme in synthesis of glutathione.
Evidence suggests that genetic variations in the promoter region of genes coding a catalytic subunit (GCLC -129T/C) and a modifier subunit (GCLM -588C/T) of GCL have a functional impact on their transcriptional activity and were associated with various disorders.
Hence, we hypothesize whether these two polymorphic variants of GCLM and GCLC genes are associated with the risk of ischemic heart disease (IHD) development in the population of Kazakhstan.
Methods.
We evaluated 360 patients with IHD and 341 control subjects.
Allele frequencies of studied promoters’ polymorphisms were detected by PCR-RFLP analysis.
Multiple logistic regression analysis was applied to assess the risk for different genotypes obtained.
Results.
The presence of -588T allele in GCLM and -129T allele in GCLC gene genotypes was associated with an increased risk of IHD (GCLM -588T: OR=3.92, p=0.003; GCLC -129T: OR=3.22, p=0.03) for general ethnically mixed group.
Analysis of each ethnical groups separately showed the higher risk tendency for Kazakhs as for GCLM -588T (OR=4.79; p=0.03) and as for GCLC -129T (OR=4.79, p=0.03).
For Russians, statistically differences for two polymorphisms were not observed.
Conclusion.
The two promoter polymorphisms of GCLM (-588C/T) and GCLC (-128T/C) are associated with an increased risk of IHD in Kazakhstan population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Skvortsova, Liliya A.& Perfilyeva, Anastassiya V.& Khussainova, Elmira& Mansharipova, Alma& Forman, Henry Jay& Djansugurova, Leyla B.. 2017. Association of GCLM -588CT and GCLC -129TC Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152323
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Skvortsova, Liliya A.…[et al.]. Association of GCLM -588CT and GCLC -129TC Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152323
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Skvortsova, Liliya A.& Perfilyeva, Anastassiya V.& Khussainova, Elmira& Mansharipova, Alma& Forman, Henry Jay& Djansugurova, Leyla B.. Association of GCLM -588CT and GCLC -129TC Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152323
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152323
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر