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Association of GCLM -588CT and GCLC -129TC Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population
Joint Authors
Perfilyeva, Anastassiya V.
Skvortsova, Liliya A.
Djansugurova, Leyla B.
Khussainova, Elmira
Mansharipova, Alma
Forman, Henry Jay
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Glutamate cysteine ligase (GCL) is a rate-limiting enzyme in synthesis of glutathione.
Evidence suggests that genetic variations in the promoter region of genes coding a catalytic subunit (GCLC -129T/C) and a modifier subunit (GCLM -588C/T) of GCL have a functional impact on their transcriptional activity and were associated with various disorders.
Hence, we hypothesize whether these two polymorphic variants of GCLM and GCLC genes are associated with the risk of ischemic heart disease (IHD) development in the population of Kazakhstan.
Methods.
We evaluated 360 patients with IHD and 341 control subjects.
Allele frequencies of studied promoters’ polymorphisms were detected by PCR-RFLP analysis.
Multiple logistic regression analysis was applied to assess the risk for different genotypes obtained.
Results.
The presence of -588T allele in GCLM and -129T allele in GCLC gene genotypes was associated with an increased risk of IHD (GCLM -588T: OR=3.92, p=0.003; GCLC -129T: OR=3.22, p=0.03) for general ethnically mixed group.
Analysis of each ethnical groups separately showed the higher risk tendency for Kazakhs as for GCLM -588T (OR=4.79; p=0.03) and as for GCLC -129T (OR=4.79, p=0.03).
For Russians, statistically differences for two polymorphisms were not observed.
Conclusion.
The two promoter polymorphisms of GCLM (-588C/T) and GCLC (-128T/C) are associated with an increased risk of IHD in Kazakhstan population.
American Psychological Association (APA)
Skvortsova, Liliya A.& Perfilyeva, Anastassiya V.& Khussainova, Elmira& Mansharipova, Alma& Forman, Henry Jay& Djansugurova, Leyla B.. 2017. Association of GCLM -588CT and GCLC -129TC Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. Disease Markers،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152323
Modern Language Association (MLA)
Skvortsova, Liliya A.…[et al.]. Association of GCLM -588CT and GCLC -129TC Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. Disease Markers No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1152323
American Medical Association (AMA)
Skvortsova, Liliya A.& Perfilyeva, Anastassiya V.& Khussainova, Elmira& Mansharipova, Alma& Forman, Henry Jay& Djansugurova, Leyla B.. Association of GCLM -588CT and GCLC -129TC Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1152323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152323