Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance

الملخص EN

Background.

It has been reported that circRNAs are differentially expressed in a wide range of cancers and could be used as a new biomarker for diagnosis.

However, the correlation between circRNAs and gastric cancer (GC) it is still unclear.

Materials and Methods.

In this study, by using real-time quantitative reverse transcription-polymerase chain reactions (qRT-PCRs), we detected the expression level of hsa_circ_0001649 in tissue and serum samples from GC patients.

Results.

We found that hsa_circ_0001649 expression was significantly downregulated in GC tissue compared with their paired paracancerous histological normal tissues (PCHNTs) (P<0.01).

We next analyzed the expression level of hsa_circ_0001649 in serum samples between preoperative and postoperative GC patients.

We found that its level in serum was significantly upregulated after surgery (P<0.01).

The area under the receiver operating characteristic (ROC) curve was 0.834.

Moreover, the expression level of hsa_circ_0001649 was significantly correlated with pathological differentiation (P=0.039).

Conclusion.

Our test suggested that hsa_circ_0001649 was significantly downregulated in GC and may become a novel potential biomarker in the diagnosis of GC.