Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance
Joint Authors
Xia, Peng
Li, Wen-han
Zhou, Zhang-jian
Guo, Kun
Wang, Ying
Zhang, Hao
Song, Yong-chun
Chang, Dong-min
Zeng, Qingnuo
Xie, Xin
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
It has been reported that circRNAs are differentially expressed in a wide range of cancers and could be used as a new biomarker for diagnosis.
However, the correlation between circRNAs and gastric cancer (GC) it is still unclear.
Materials and Methods.
In this study, by using real-time quantitative reverse transcription-polymerase chain reactions (qRT-PCRs), we detected the expression level of hsa_circ_0001649 in tissue and serum samples from GC patients.
Results.
We found that hsa_circ_0001649 expression was significantly downregulated in GC tissue compared with their paired paracancerous histological normal tissues (PCHNTs) (P<0.01).
We next analyzed the expression level of hsa_circ_0001649 in serum samples between preoperative and postoperative GC patients.
We found that its level in serum was significantly upregulated after surgery (P<0.01).
The area under the receiver operating characteristic (ROC) curve was 0.834.
Moreover, the expression level of hsa_circ_0001649 was significantly correlated with pathological differentiation (P=0.039).
Conclusion.
Our test suggested that hsa_circ_0001649 was significantly downregulated in GC and may become a novel potential biomarker in the diagnosis of GC.
American Psychological Association (APA)
Li, Wen-han& Song, Yong-chun& Zhang, Hao& Zhou, Zhang-jian& Xie, Xin& Zeng, Qingnuo…[et al.]. 2017. Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance. Disease Markers،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152341
Modern Language Association (MLA)
Li, Wen-han…[et al.]. Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance. Disease Markers No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1152341
American Medical Association (AMA)
Li, Wen-han& Song, Yong-chun& Zhang, Hao& Zhou, Zhang-jian& Xie, Xin& Zeng, Qingnuo…[et al.]. Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152341