Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients
المؤلفون المشاركون
Hu, Yunzhao
Huang, Yuli
Zhou, Haobin
Wu, Yu
Yang, You
Li, Wensheng
Lu, Jianhua
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker of chronic inflammation and is considered to be a risk factor for coronary artery disease (CAD) in Caucasians.
This study investigated the role of suPAR in young Chinese patients with CAD.
Methods.
The study involved a total of 196 consecutive young (age ≤ 55 years) patients with angiographically proven CAD and 188 age-matched non-CAD individuals as controls.
Traditional risk factors were evaluated using conventional assays, and levels of suPAR were measured by sandwich enzyme-linked immunosorbent assays.
Results.
Levels of suPAR were significantly correlated with age (r=0.20, P=0.04), smoking (r=0.33, P=0.008), body mass index (r=0.21, P=0.03), and high-sensitivity C-reactive protein (hs-CRP; r=0.31, P=0.01).
Multivariate logistic regression analysis showed that male sex (odds ratio (OR) = 3.12; 95% confidence interval (CI) = 1.18–8.25, P=0.02), smoking (OR = 3.41, 95% CI = 1.55–7.50, P=0.002), triglyceride (OR = 1.89, 95% CI = 1.10–3.25, P=0.02), high-sensitivity C-reactive protein (OR = 1.24, 95% CI = 1.02–0.03, P=0.03), and suPAR (OR = 1.37, 95% CI = 1.09–1.72, P=0.007) were independently associated with CAD risk in young patients.
Conclusions.
SuPAR is a novel independent risk factor for CAD in young Chinese patients.
Further studies evaluating the effect of anti-inflammatory treatment on the suPAR levels and the risk of CAD are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Yuli& Zhou, Haobin& Wu, Yu& Yang, You& Li, Wensheng& Lu, Jianhua…[et al.]. 2017. Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients. Disease Markers،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152346
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Yuli…[et al.]. Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients. Disease Markers No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1152346
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Yuli& Zhou, Haobin& Wu, Yu& Yang, You& Li, Wensheng& Lu, Jianhua…[et al.]. Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152346
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152346
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر