Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients
Joint Authors
Hu, Yunzhao
Huang, Yuli
Zhou, Haobin
Wu, Yu
Yang, You
Li, Wensheng
Lu, Jianhua
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker of chronic inflammation and is considered to be a risk factor for coronary artery disease (CAD) in Caucasians.
This study investigated the role of suPAR in young Chinese patients with CAD.
Methods.
The study involved a total of 196 consecutive young (age ≤ 55 years) patients with angiographically proven CAD and 188 age-matched non-CAD individuals as controls.
Traditional risk factors were evaluated using conventional assays, and levels of suPAR were measured by sandwich enzyme-linked immunosorbent assays.
Results.
Levels of suPAR were significantly correlated with age (r=0.20, P=0.04), smoking (r=0.33, P=0.008), body mass index (r=0.21, P=0.03), and high-sensitivity C-reactive protein (hs-CRP; r=0.31, P=0.01).
Multivariate logistic regression analysis showed that male sex (odds ratio (OR) = 3.12; 95% confidence interval (CI) = 1.18–8.25, P=0.02), smoking (OR = 3.41, 95% CI = 1.55–7.50, P=0.002), triglyceride (OR = 1.89, 95% CI = 1.10–3.25, P=0.02), high-sensitivity C-reactive protein (OR = 1.24, 95% CI = 1.02–0.03, P=0.03), and suPAR (OR = 1.37, 95% CI = 1.09–1.72, P=0.007) were independently associated with CAD risk in young patients.
Conclusions.
SuPAR is a novel independent risk factor for CAD in young Chinese patients.
Further studies evaluating the effect of anti-inflammatory treatment on the suPAR levels and the risk of CAD are needed.
American Psychological Association (APA)
Huang, Yuli& Zhou, Haobin& Wu, Yu& Yang, You& Li, Wensheng& Lu, Jianhua…[et al.]. 2017. Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients. Disease Markers،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152346
Modern Language Association (MLA)
Huang, Yuli…[et al.]. Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients. Disease Markers No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1152346
American Medical Association (AMA)
Huang, Yuli& Zhou, Haobin& Wu, Yu& Yang, You& Li, Wensheng& Lu, Jianhua…[et al.]. Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152346