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Serum Autoantibodies against STIP1 as a Potential Biomarker in the Diagnosis of Esophageal Squamous Cell Carcinoma
المؤلفون المشاركون
Xu, Liyan
Li, Enmin
Hong, Chaoquan
Xu, Yi-Wei
Peng, Yu-Hui
Liu, Can-Tong
Huang, Xin-Yi
Huang, Li-Sheng
Luo, Yu-Hao
Guo, Hai-Peng
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-09
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Esophageal squamous cell carcinoma (ESCC) remains one of the leading causes of cancer-related mortality around the world.
The identification of novel serum biomarkers is required for early detection of ESCC.
This study was designed to elucidate whether autoantibodies against STIP1 could be a diagnostic biomarker in ESCC.
An enzyme-linked immunosorbent assay was performed to detect serum levels of STIP1 autoantibodies in a training cohort (148 ESCC patients and 111 controls) and a validation cohort (60 ESCC patients and 40 controls).
Mann–Whitney’s U test showed that ESCC patients in two cohorts have higher levels of autoantibodies against STIP1 when compared to controls (P<0.001).
According to receiver operating characteristic analysis, the sensitivity, specificity, and area under the curve (AUC) of autoantibodies against STIP1 in ESCC were 41.9%, 90.1%, and 0.682 in the training cohort and 40.0%, 92.5%, and 0.710 in the validation cohort, respectively.
Moreover, detection of autoantibodies against STIP1 could discriminate early-stage ESCC patients from controls, with sensitivity, specificity, and AUC of 35.7%, 90.1%, and 0.684 in the training cohort and 38.5%, 92.5%, and 0.756 in the validation cohort, respectively.
Our findings indicated that autoantibodies against STIP1 might be a useful biomarker for early-stage ESCC detection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Yi-Wei& Liu, Can-Tong& Huang, Xin-Yi& Huang, Li-Sheng& Luo, Yu-Hao& Hong, Chaoquan…[et al.]. 2017. Serum Autoantibodies against STIP1 as a Potential Biomarker in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152384
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Yi-Wei…[et al.]. Serum Autoantibodies against STIP1 as a Potential Biomarker in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152384
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Yi-Wei& Liu, Can-Tong& Huang, Xin-Yi& Huang, Li-Sheng& Luo, Yu-Hao& Hong, Chaoquan…[et al.]. Serum Autoantibodies against STIP1 as a Potential Biomarker in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152384
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152384
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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