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Serum Autoantibodies against STIP1 as a Potential Biomarker in the Diagnosis of Esophageal Squamous Cell Carcinoma
Joint Authors
Xu, Liyan
Li, Enmin
Hong, Chaoquan
Xu, Yi-Wei
Peng, Yu-Hui
Liu, Can-Tong
Huang, Xin-Yi
Huang, Li-Sheng
Luo, Yu-Hao
Guo, Hai-Peng
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Esophageal squamous cell carcinoma (ESCC) remains one of the leading causes of cancer-related mortality around the world.
The identification of novel serum biomarkers is required for early detection of ESCC.
This study was designed to elucidate whether autoantibodies against STIP1 could be a diagnostic biomarker in ESCC.
An enzyme-linked immunosorbent assay was performed to detect serum levels of STIP1 autoantibodies in a training cohort (148 ESCC patients and 111 controls) and a validation cohort (60 ESCC patients and 40 controls).
Mann–Whitney’s U test showed that ESCC patients in two cohorts have higher levels of autoantibodies against STIP1 when compared to controls (P<0.001).
According to receiver operating characteristic analysis, the sensitivity, specificity, and area under the curve (AUC) of autoantibodies against STIP1 in ESCC were 41.9%, 90.1%, and 0.682 in the training cohort and 40.0%, 92.5%, and 0.710 in the validation cohort, respectively.
Moreover, detection of autoantibodies against STIP1 could discriminate early-stage ESCC patients from controls, with sensitivity, specificity, and AUC of 35.7%, 90.1%, and 0.684 in the training cohort and 38.5%, 92.5%, and 0.756 in the validation cohort, respectively.
Our findings indicated that autoantibodies against STIP1 might be a useful biomarker for early-stage ESCC detection.
American Psychological Association (APA)
Xu, Yi-Wei& Liu, Can-Tong& Huang, Xin-Yi& Huang, Li-Sheng& Luo, Yu-Hao& Hong, Chaoquan…[et al.]. 2017. Serum Autoantibodies against STIP1 as a Potential Biomarker in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease Markers،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152384
Modern Language Association (MLA)
Xu, Yi-Wei…[et al.]. Serum Autoantibodies against STIP1 as a Potential Biomarker in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease Markers No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1152384
American Medical Association (AMA)
Xu, Yi-Wei& Liu, Can-Tong& Huang, Xin-Yi& Huang, Li-Sheng& Luo, Yu-Hao& Hong, Chaoquan…[et al.]. Serum Autoantibodies against STIP1 as a Potential Biomarker in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1152384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152384