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Circulating Tumor Cells Were Associated with the Number of T Lymphocyte Subsets and NK Cells in Peripheral Blood in Advanced Non-Small-Cell Lung Cancer
المؤلفون المشاركون
Song, Yong
Zhang, Fang
Lv, Tang-feng
Ye, Liang
Li, Huijuan
Yang, Linfei
Gu, Wei
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In this study, we aim to investigate the correlation between circulating tumor cells (CTCs) and the T lymphocyte subsets and NK cells in peripheral blood in non-small-cell lung cancer (NSCLC).
The peripheral blood CTCs were determined by SET-iFISH.
Flow cytometry was used to determine the distribution of T lymphocyte subsets and NK cells.
Forty-one (49%) patients showed positivity for CTCs.
Logistic regression analysis revealed CTC number was negatively correlated with the ratio of CD3+, CD4+, CD4+/CD8+, and NK % in patients at stage IV, while in a positive correlation was noticed between CTC number and regulatory T cell (Tregs) ratio in these patients.
Multivariate analysis was performed in combination with the clinical-pathological materials to identify the risk factors for CTC positivity.
Differentiation, NSCLC stage, percentages of CD3+CD4+ cells, Tregs, and NK cells were the independent risk factors for CTCs.
CTCs were associated with the decrease of immune surveillance in the peripheral blood in NSCLC patients.
The decrease of immune surveillance contributed to the escape of CTCs from the killing effects of the immunocytes, as well as the formation of metastasized lesions in the target organs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ye, Liang& Zhang, Fang& Li, Huijuan& Yang, Linfei& Lv, Tang-feng& Gu, Wei…[et al.]. 2017. Circulating Tumor Cells Were Associated with the Number of T Lymphocyte Subsets and NK Cells in Peripheral Blood in Advanced Non-Small-Cell Lung Cancer. Disease Markers،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152391
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ye, Liang…[et al.]. Circulating Tumor Cells Were Associated with the Number of T Lymphocyte Subsets and NK Cells in Peripheral Blood in Advanced Non-Small-Cell Lung Cancer. Disease Markers No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1152391
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ye, Liang& Zhang, Fang& Li, Huijuan& Yang, Linfei& Lv, Tang-feng& Gu, Wei…[et al.]. Circulating Tumor Cells Were Associated with the Number of T Lymphocyte Subsets and NK Cells in Peripheral Blood in Advanced Non-Small-Cell Lung Cancer. Disease Markers. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1152391
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1152391
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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